Factor XIII: Difference between revisions
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<StructureSection load='1ggt' size='350' side='right' caption='Human Factor XIII dimer (PDB entry [[1ggt]])' scene='Factor_XIII/Cv/1'> | |||
== Function == | |||
[[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>. | [[Factor XIII]] (FXIII) belongs to the blood coagulation system and crosslinks fibrin resulting in an insoluble clot. FXIII is activated by thrombin which cleaves it and releases an activation peptide<ref>PMID:17842715</ref>. | ||
== Disease == | |||
FXIII deficiency causes internal bleeding. | |||
</StructureSection> | |||
== 3D Structures of Factor XIII == | == 3D Structures of Factor XIII == | ||
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[[1ggt]] – hFXIII - human <br /> | [[1ggt]] – hFXIII - human <br /> | ||
[[8cmt]], [[8cmu]] - hFXIII – Cryo EM<br /> | |||
[[1ex0]] – hFXIII zymogen (mutant)<br /> | [[1ex0]] – hFXIII zymogen (mutant)<br /> | ||
[[1fie]] – hFXIII subunit A<br /> | [[1fie]] – hFXIII subunit A<br /> | ||
[[1f13]] - hFXIII zymogen subunit A dimer<br /> | [[1f13]] - hFXIII zymogen subunit A dimer<br /> | ||
[[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | [[4kty]] - hFXIII subunit A + peptide-like ligand<br /> | ||
[[5mhl]], [[5mhm]], [[5mhn]], [[5mho]] - hFXIII subunit A (mutant) + peptide inhibitor<br /> | |||
[[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | [[1ggy]], [[1qrk]], [[1ggu]], [[1evu]] – hFXIII + ion<br /> | ||
[[1de7]] – hFXIII activation peptide + α-thrombin<br /> | [[1de7]] – hFXIII activation peptide + α-thrombin<br /> | ||
