Flavin reductase: Difference between revisions

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<StructureSection load='' size='350' side='right' scene='49/490853/Cv/1' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>


<StructureSection load='1he2' size='350' side='right' scene='' caption='Human flavin reductase complex with biliverdin IX α and NADP (PDB code [[1he2]]) '>
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== Function ==
== Function ==


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FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia.  Bacterial FR are used to sensitize tumors to drugs.
FR catalytic reaction is the basis of the therapeutic use of methylene blue or riboflavin in the treatment of methemoglobinemia.  Bacterial FR are used to sensitize tumors to drugs.
== Structural insights ==
The <scene name='49/490853/Cv/4'>NADP containing active site can accommodate a variety of ligands</scene> because the binding is achieved mainly via hydrophobic interactions ({{Template:ColorKey_Hydrophobic}},  {{Template:ColorKey_Polar}}).<ref>PMID:11224564</ref>
</StructureSection>
</StructureSection>


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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*NADPH-dependent Flavin reductase or biliverdin IX beta reductase
**[[8ell]], [[8elm]] – hFR – human
**[[1hdo]], [[7er6]], [[9c18]] - hFR + NADP <br />
**[[6opl]] – hFR (mutant) + NADP <br />
**[[1he2]] - hFR + biliverdin IX α + NADP<BR />
**[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
**[[1he4]] - hFR + FMN + NADP<BR />
**[[1he5]] - hFR + lumichrome + NADP<BR />
**[[5ooh]] – hFR + NADP + erythrosine<br />
**[[5oog]] – hFR + NADP + phloxine + cyanosine<br />
**[[7er7]], [[7er8]], [[7er9]], [[7era]], [[7erb]], [[7erc]], [[7erd]], [[7ere]] – hFR + NADP + drug<br />
**[[8k4k]], [[9c16]], [[9c17]] – hFR + NADP + inhibitor<br />
**[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''<br />
**[[5cho]] - FR + FAD – uncultured bacteria<br />
**[[1qfj]] – FR – ''Escherichia coli''<br />
**[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
**[[2bkj]] - VhFR + NAD + FMN<br />
*NADH-dependent Flavin reductase


[[1qfj]] – FR – ''Escherichia coli''<br />
**[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
[[1bkj]] – VhFR + FMN – ''Vibrio harveyi''<br />
**[[1rz1]] - GtFR + FAD + NAD<br />
[[2bkj]] - VhFR + NAD + FMN<br />
**[[5n6q]] - PpFR + FMN – ''Pseudomonas putida''<br />
[[1hdo]] - hFR + NADP - human<br />
**[[4uth]] - PpFR (mutant) + FMN <br />
[[1he2]] - hFR + biliverdin IX α + NADP<BR />
**[[5lnj]], [[5lni]], [[4uti]], [[4utj]] - PpFR (mutant) + FMN derivative + coumarin derivative<br />
[[1he3]] - hFR + mesobiliverdin IV α + NADP<BR />
**[[2d36]] - StFR + FMN – ''Sulfurisphaera tokodaii''<br />
[[1he4]] - hFR + FMN + NADP<BR />
**[[2d37]] - StFR + FMN + NAD<br />
[[1he5]] - hFR + lumichrome + NADP<BR />
**[[2d38]] - StFR + FMN + NADP<br />
[[1rz0]] – GtFR + FAD – ''Geobacillus thermoglucosidasius''<br />
**[[9fd4]], [[9fd5]] - FR + FAD – ''Streptomyces albogriseolus''<br />
[[1rz1]] - GtFR + FAD + NAD<br />
**[[8ct0]] - FR + FAD + NAD – ''Kitasatospora aureofaciens''<br />
[[3pft]] - FR (mutant) + FMN – ''Mycobacterium goodii''


}}
== References ==
== References ==
<references/>
<references/>
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