5hix: Difference between revisions
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==Cocrystal structure of an anti-parallel DNA G-quadruplex and a tetra-Quinoline Foldamer== | |||
<StructureSection load='5hix' size='340' side='right'caption='[[5hix]], [[Resolution|resolution]] 2.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hix]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HIX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=61Q:4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-({[4-(3-aminopropoxy)-8-nitroquinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinolin-2-yl]carbonyl}amino)quinoline-2-carboxylic+acid'>61Q</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hix OCA], [https://pdbe.org/5hix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hix RCSB], [https://www.ebi.ac.uk/pdbsum/5hix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hix ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G4 T4 G4 )2 with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4 T4 G4 )2 in the solid state are observed. | |||
Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.,Mandal PK, Baptiste B, Langlois d'Estaintot B, Kauffmann B, Huc I Chembiochem. 2016 Oct 17;17(20):1911-1914. doi: 10.1002/cbic.201600281. Epub 2016, Aug 19. PMID:27472456<ref>PMID:27472456</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: Baptiste | <div class="pdbe-citations 5hix" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Kauffmann | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Baptiste B]] | |||
[[Category: Huc I]] | |||
[[Category: Kauffmann B]] | |||
[[Category: Langlois d'Estaintot B]] | |||
[[Category: Mandal PK]] | |||
Latest revision as of 07:38, 9 August 2023
Cocrystal structure of an anti-parallel DNA G-quadruplex and a tetra-Quinoline Foldamer
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