2n0u: Difference between revisions
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==Mdmx-057== | ==Mdmx-057== | ||
<StructureSection load='2n0u' size='340' side='right' caption='[[2n0u | <StructureSection load='2n0u' size='340' side='right'caption='[[2n0u]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2n0u]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0U OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2n0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N0U FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=48M:4-[(4S,5R)-4-(3-CHLOROPHENYL)-5-(4-CHLOROPHENYL)-1-(3-OXIDANYLIDENEPIPERAZIN-1-YL)CARBONYL-4,5-DIHYDROIMIDAZOL-2-YL]-3-PROPAN-2-YLOXY-BENZENECARBONITRILE'>48M</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48M:4-[(4S,5R)-4-(3-CHLOROPHENYL)-5-(4-CHLOROPHENYL)-1-(3-OXIDANYLIDENEPIPERAZIN-1-YL)CARBONYL-4,5-DIHYDROIMIDAZOL-2-YL]-3-PROPAN-2-YLOXY-BENZENECARBONITRILE'>48M</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n0u OCA], [https://pdbe.org/2n0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n0u RCSB], [https://www.ebi.ac.uk/pdbsum/2n0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n0u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref> | ||
==See Also== | |||
*[[MDM4|MDM4]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Grace CR]] | ||
[[Category: | [[Category: Kriwacki RW]] | ||
