DnaA: Difference between revisions

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'''DnaA''' activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>

'''DnaA''' or '''chromosomal replication initiator protein DnaA''' activates initiation of DNA replication in prokaryotes. DnaA promotes the unwinding of the DNA helix. The cellular concentration of DnaA determines the initiation of DNA replication. Active DnaA is bound to ATP. DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>

<scene name='50/509255/Cv/2'>Protein-DNA interface</scene> ([[1j1v]]).<ref>PMID:12682358</ref>

For more details see [[Molecular Playground/DNA replication initiator DnaA]].

</StructureSection>

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[[1j1v]] – EcDnaA DNA binding domain + DNA – ''Escherichia coli''

[[2e0g]] - EcDnaA N terminal – NMR

[[2jmp]] - DnaA N terminal – Mycoplasma genitalium – NMR

[[2jmp]] - DnaA N terminal – ''Mycoplasma genitalium'' – NMR

[[2z4r]], [[2z4s]] - DnaA domain III – ''Thermotoga maritima''

[[2wp0]] - DnaA N terminal + HOBA – ''Helicobacter pylori''

[[3pvp]], [[3pvv]] - DnaA DNA binding domain + DNA – ''Mycobacterium tuberculosis''

[[3pvp]], [[3pvv]] - DnaA DNA binding domain + DNA – ''Mycobacterium tuberculosis''

[[4tps]] - BsDnaA domain I 1-82 + SirA – ''Bacillus subtilis''

[[8bv3]] - BsDnaA domain III 106-346

[[8btg]] - BsDnaA + DNA – Cryo EM

== References ==

[[Category:Topic Page]]

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-<StructureSection load='1j1v' size='350' side='right' scene='' caption='E. coli DnaA complex with DNA ([[1j1v]])'>
+<StructureSection load='' size='350' side='right' scene='50/509255/Cv/1' caption='E. coli DnaA complex with DNA ([[1j1v]])'>
-'''DnaA''' activates initiation of DNA replication in prokaryotes.  DnaA promotes the unwinding of the DNA helix.  The cellular concentration of DnaA determines the initiation of DNA replication.  Active DnaA is bound to ATP.  DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>
+'''DnaA''' or '''chromosomal replication initiator protein DnaA''' activates initiation of DNA replication in prokaryotes.  DnaA promotes the unwinding of the DNA helix.  The cellular concentration of DnaA determines the initiation of DNA replication.  Active DnaA is bound to ATP.  DnaA binds to DNA at a specific 9 base pair DnaA box in oriC (origin of replication sequence). <ref>PMID:17435790</ref>
+<scene name='50/509255/Cv/2'>Protein-DNA interface</scene> ([[1j1v]]).<ref>PMID:12682358</ref>
 For more details see [[Molecular Playground/DNA replication initiator DnaA]].
 </StructureSection>
@@ Line 14: / Line 35: @@
 [[1j1v]] – EcDnaA DNA binding domain + DNA – ''Escherichia coli''<br />
 [[2e0g]] - EcDnaA N terminal – NMR<BR />
-[[2jmp]] - DnaA N terminal – Mycoplasma genitalium – NMR<BR />
+[[2jmp]] - DnaA N terminal – ''Mycoplasma genitalium'' – NMR<BR />
 [[2z4r]], [[2z4s]] - DnaA domain III – ''Thermotoga maritima''<br />
 [[2wp0]] - DnaA N terminal + HOBA – ''Helicobacter pylori''<br />
-[[3pvp]], [[3pvv]] - DnaA DNA binding domain + DNA – ''Mycobacterium tuberculosis''
+[[3pvp]], [[3pvv]] - DnaA DNA binding domain + DNA – ''Mycobacterium tuberculosis''<br />
+[[4tps]] - BsDnaA domain I 1-82 + SirA – ''Bacillus subtilis''<br />
+[[8bv3]] - BsDnaA domain III 106-346<br />
+[[8btg]] - BsDnaA + DNA – Cryo EM<br />
 == References ==
 <references/>
+[[Category:Topic Page]]