3h8i: Difference between revisions
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==The first X-ray structure of a sulfide:quinone oxidoreductase: Insights into sulfide oxidation mechanism== | ==The first X-ray structure of a sulfide:quinone oxidoreductase: Insights into sulfide oxidation mechanism== | ||
<StructureSection load='3h8i' size='340' side='right' caption='[[3h8i]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='3h8i' size='340' side='right'caption='[[3h8i]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3h8i]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3h8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acidianus_ambivalens Acidianus ambivalens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H8I FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=S3H:TRISULFANE'>S3H</scene></td></tr> | ||
< | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h8i OCA], [https://pdbe.org/3h8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h8i RCSB], [https://www.ebi.ac.uk/pdbsum/3h8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h8i ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/SQRD_ACIAM SQRD_ACIAM] Catalyzes the oxidation of sulfides, such as hydrogen sulfide, with the help of a quinone. Has the highest activity with caldariella quinone and decylubiquinone, and lower activity with naphtoquinones. Consecutive reaction cycles lead to the accumulation of a polysulfide product on the active site Cys residues; these products are released when they exceed a critical length, typically as cyclooctasulfur.<ref>PMID:19438211</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h8i_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/3h8i_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</div> | </div> | ||
<div class="pdbe-citations 3h8i" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3h8i" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Quinone reductase 3D structures|Quinone reductase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Acidianus ambivalens]] | [[Category: Acidianus ambivalens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Archer | [[Category: Archer M]] | ||
[[Category: Bandeiras | [[Category: Bandeiras TM]] | ||
[[Category: Brito | [[Category: Brito JA]] | ||
[[Category: Pereira | [[Category: Pereira MM]] | ||
[[Category: Sousa | [[Category: Sousa FL]] | ||
[[Category: Stelter | [[Category: Stelter M]] | ||
[[Category: Teixeira | [[Category: Teixeira M]] | ||
[[Category: Vonrhein | [[Category: Vonrhein C]] | ||
