Factor VIII: Difference between revisions
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[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]]. | [[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]]. | ||
<scene name='45/451726/Cv/ | <scene name='45/451726/Cv/7'>First Ca coordination site</scene>. | ||
<scene name='45/451726/Cv/8'>Second Ca coordination site</scene>. | |||
<scene name='45/451726/Cv/9'>First Cu coordination site</scene>. | |||
<scene name='45/451726/Cv/10'>Second Cu coordination site</scene> (PDB code [[2r7e]]).<ref>PMID:17965321</ref> | |||
== Disease == | == Disease == | ||
Defects in the protein result in hemophilia A. | Defects in the protein result in [[Hemophilia|hemophilia]] A. | ||
== Relevance == | == Relevance == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]] – hFVIII – human<br /> | [[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII 19-760+1582-2351 – human<br /> | ||
[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br /> | [[6mf0]] – h/pFVIII<br /> | ||
[[3hnb]], [[3hny]], [[3hob]], [[4pt6]] – hFVIII light chain C2 domain 2189-2347<br /> | |||
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br /> | [[1d7p]] - hFVIII light chain C2 domain (mutant)<br /> | ||
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br /> | [[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br /> | ||
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br /> | [[7k66]], [[7kbt]] – h/pFVIII + antibody<br /> | ||
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br /> | |||
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br /> | |||
[[3j2s]] - hFVIII light chain 1710-2356<br /> | |||
[[5k8d]] - hFVIII heavy chain + light chain residues 104-329<br /> | |||
[[7kwo]] – hFVIII + VWF-XTEN<br /> | |||
[[4mo3]] - pFVIII light chain C2 domain – pig<br /> | |||
[[7s0p]] - pFVIII light chain C2 domain + phosphatidylserine<br /> | |||
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br /> | [[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 08:56, 27 February 2023
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3D Structures of Factor VIII
Updated on 27-February-2023
factor IXa, Factor VIII (Hebrew), 2r7e, hemophilia, 6mf2 – hFVIII 19-760+1582-2351 – human
6mf0 – h/pFVIII
3hnb, 3hny, 3hob, 4pt6 – hFVIII light chain C2 domain 2189-2347
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
7k66, 7kbt – h/pFVIII + antibody
4xzu - hFVIII light chain C2 domain + monoclonal Fab
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
3j2s - hFVIII light chain 1710-2356
5k8d - hFVIII heavy chain + light chain residues 104-329
7kwo – hFVIII + VWF-XTEN
4mo3 - pFVIII light chain C2 domain – pig
7s0p - pFVIII light chain C2 domain + phosphatidylserine
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse
