Prestin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (10 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='' size='400' side='right' caption='Rat prestin STAS domain complex with Cl- ion and ethylene glycol (PDB code [[5euu]])' scene='72/725863/Cv/1'> | ||
== Function == | == Function == | ||
| Line 7: | Line 7: | ||
== Disease == | == Disease == | ||
Mutations in Pre are associated with non-syndromic hearing loss. | Mutations in Pre are associated with non-syndromic hearing loss<ref>PMID:12719379</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
Pre C-terminal is mainly composed of a STAS (Sulfate Transporters and Anti-Sigma factor antagonist) domain<ref>PMID:20471983</ref>. | Pre C-terminal is mainly composed of a STAS (Sulfate Transporters and Anti-Sigma factor antagonist) domain<ref>PMID:20471983</ref>. | ||
*<scene name='72/725863/Cv/4'>1st Cl coordination site</scene>. Water molecules are shown as red spheres. | |||
*<scene name='72/725863/Cv/5'>2nd Cl coordination site</scene>. | |||
</StructureSection> | </StructureSection> | ||
| Line 19: | Line 20: | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[7lgu]], [[7lgw]], [[7lh3]], [[7v73]], [[7v74]] – hPre – human – Cryo EM<br /> | |||
[[7lh2]], [[7v75]] – hPre + salicylate – Cryo EM<br /> | |||
[[3llo]] – rPre STAS domain – rat<br /> | [[3llo]] – rPre STAS domain – rat<br /> | ||
[[5eus]] – rPre STAS domain + Br<br /> | [[5eus]] – rPre STAS domain + Br<br /> | ||
| Line 25: | Line 28: | ||
[[5euw]] – rPre STAS domain + NO3<br /> | [[5euw]] – rPre STAS domain + NO3<br /> | ||
[[5eux]] – rPre STAS domain + CNS<br /> | [[5eux]] – rPre STAS domain + CNS<br /> | ||
[[7sun]] – Pre – gerbil – Cryo EM<br /> | |||
[[5ezb]] – Pre STAS domain - chicken<br /> | [[5ezb]] – Pre STAS domain - chicken<br /> | ||
[[7s8x]], [[7s9b]], [[7s9c]], [[7s9d]], [[8uc1]] – dPre – dolphin – Cryo EM<br /> | |||
[[7s9a]], [[7s9e]] – dPre + salicylate – Cryo EM<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
Latest revision as of 07:44, 13 July 2026
| ||||||||||||
3D Structures of prestin
Updated on 13-July-2026
STAS domain of the SLC26 anion transporter prestin, 7lgw, 7lh3, 7v73, 7v74 – hPre – human – Cryo EM
7lh2, 7v75 – hPre + salicylate – Cryo EM
3llo – rPre STAS domain – rat
5eus – rPre STAS domain + Br
5euu – rPre STAS domain + Cl
5euz – rPre STAS domain + I
5euw – rPre STAS domain + NO3
5eux – rPre STAS domain + CNS
7sun – Pre – gerbil – Cryo EM
5ezb – Pre STAS domain - chicken
7s8x, 7s9b, 7s9c, 7s9d, 8uc1 – dPre – dolphin – Cryo EM
7s9a, 7s9e – dPre + salicylate – Cryo EM
