Tdp-43: Difference between revisions
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TDP-43 helical stabilizers | TDP-43 helical stabilizers | ||
<StructureSection load='2n2cligalza0.pdb.gz' size=' | <StructureSection load='2n2cligalza0.pdb.gz' size='350' side='right' caption='Compound A is the best current binder to the healthy helical tdp-43 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037571/)' scene=''> | ||
This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils | This is the healthy helical coil (residues 307-349) of TDP-43. A key biomolecular cause of ALS appears to be a helix-sheet transition in this area, leading to the formation of protein fibrils. | ||
== Function == | == Function == | ||
'''Tdp-43''' or '''TAR DNA-binding protein 43''' is a heterogeneous nuclear ribonucleoprotein which has crucial roles in gene expression and alternative splicing, stress response, neuronal functions such as neurite outgrowth and many other cellular processes<ref>PMID:17981595</ref>. | |||
== Disease == | == Disease == | ||
Tdp-43 mutations were found ion familial and sporadic ALS patients<ref>PMID:18309045</ref>. Phosphorylated Tdp-43 is deposited as cytoplasmic and intranuclear inclusions in brains of patients with frontotemporal lobar degeneration and ALS<ref>PMID:18546284</ref>. | |||
== Structural highlights == | == Structural highlights == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. | ||
</StructureSection> | |||
== 3D Structures of Tdp-43 == | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2cqg]] – hTDP-43 RRM1 domain – human - NMR <br /> | |||
[[1wf0]] – hTDP-43 RRM2 domain - NMR <br /> | |||
[[5mrg]], [[2n4p]], [[5x4f]] – hTDP-43 N-terminal domain - NMR <br /> | |||
[[5mdi]] – hTDP-43 N-terminal domain <br /> | |||
[[2n2c]], [[2n3x]] – hTDP-43 prion-like helix - NMR <br /> | |||
[[2n4g]], [[2n4h]] – hTDP-43 prion-like helix (mutant) - NMR <br /> | |||
[[4y0f]], [[4iuf]] – hTDP-43 RRM1 domain + DNA <br /> | |||
[[4y00]] – hTDP-43 RRM1 domain (mutant) + DNA <br /> | |||
[[4bs2]] – hTDP-43 RRM1+RRM2 domains + RNA - NMR<br /> | |||
[[3d2w]] – TDP-43 RRM2 domain + DNA - mouse<br /> | |||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 21:36, 17 March 2018
TDP-43 helical stabilizers
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3D Structures of Tdp-43
Updated on 17-March-2018
2cqg – hTDP-43 RRM1 domain – human - NMR
1wf0 – hTDP-43 RRM2 domain - NMR
5mrg, 2n4p, 5x4f – hTDP-43 N-terminal domain - NMR
5mdi – hTDP-43 N-terminal domain
2n2c, 2n3x – hTDP-43 prion-like helix - NMR
2n4g, 2n4h – hTDP-43 prion-like helix (mutant) - NMR
4y0f, 4iuf – hTDP-43 RRM1 domain + DNA
4y00 – hTDP-43 RRM1 domain (mutant) + DNA
4bs2 – hTDP-43 RRM1+RRM2 domains + RNA - NMR
3d2w – TDP-43 RRM2 domain + DNA - mouse
