|
|
| (13 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| [[Image:3ffn.jpg|left|300px]]
| | <StructureSection load='1h1v' size='350' side='right' caption='Human gelsolin S4-S6 (gold) complex with actin (cyan), ATP and Ca+2 ion (green) (PDB entry [[1h1v]])' scene='41/410297/Cv/3'> |
| <!-- | | __TOC__ |
| {{Structure
| |
| |PDB=3ffn|SIZE=350|SCENE=|CAPTION=Gelsolin (GLS), 3FFN
| |
| |SITE=
| |
| |LIGAND=
| |
| |ACTIVITY=
| |
| |GENE=
| |
| |DOMAIN=
| |
| |RELATEDENTRY=
| |
| |RESOURCES=
| |
| }}
| |
| --> | |
| {{STRUCTURE_2fgh| PDB=2fgh | SCENE= |CAPTION=Gelsolin (GLS) dimer complex with ATP (red), [[2fgh]] }}
| |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| == Function == | | == Function == |
|
| |
|
| [[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>. | | [[Gelsolin]] (GLS) is a protein regulator of actin assembly and disassembly<ref>PMID:10559185</ref>. Binding of Ca+2 ion to GLS induces conformational change which enables it to bind actin. |
|
| |
|
| == Structural highlights == | | == Structural highlights == |
|
| |
|
| The image at the top left corresponds to the human gelsolin ([[3ffn]]), it has <scene name='Gelsolin/Cv/2'>dimeric form</scene>. It contains 6 homologous domains S1 to S6. | | GLS contains 6 homologous domains S1 to S6. The human GLS domains span residues: 15-135, 136-248, 249-367, 394-513, 514-619 and 620-734. <scene name='41/410297/Cv/6'>S4-S6 are shown</scene>. The <scene name='41/410297/Cv/7'>binding site of Ca+2 ion includes Glu, Asp and 2 carbonyl oxygens</scene><ref>PMID:12460571</ref>. |
| | |
| == 3D Structures of GLS == | |
| | |
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| |
| {{#tree:id=OrganizedByTopic|openlevels=0|
| |
| | |
| * GLS
| |
| | |
| **[[3ffn]] – hGLS – human <br />
| |
| **[[2fgh]] – hoGLS+ATP – horse <br />
| |
| **[[1d0n]] - hoGLS <br />
| |
| **[[2x1o]], [[2x1p]], [[2x1q]] – GLS nanobody - Llama
| |
| | |
| * GLS domains S1-S3
| |
| | |
| **[[3ffk]] – hGLS +actin <br />
| |
| **[[1rgi]] - hoGLS +actin <br />
| |
| | |
| * GLS domains S4-S6
| |
| | |
| **[[1h1v]] - hGLS +actin<br />
| |
| **[[1nph]] - mGLS +Ca – mouse<br />
| |
| | |
| * GLS domain S1
| |
|
| |
|
| **[[2ff3]] - hGLS +N-WASP+actin<br />
| | == 3D Structures of gelsolin == |
| **[[2ff6]] - hGLS +Ciboulot domain 2+actin<br />
| | [[Gelsolin 3D structures]] |
| **[1mdu]] - hGLS +chActin – chicken<br />
| |
| **[[1d4x]] - hGLS +CeActin+Mg-ATP – ''Caenorhabditis elegans''<br />
| |
| **[[1esv]] - hGLS +rActin+latrunculin – rabbit<br />
| |
| **[[1eqy]] - hGLS +rActin<br />
| |
| **[[1yvn]] - hGLS +yActin (mutant) – yeast<br />
| |
| **[[1yag]] - hGLS +yActin<br />
| |
| **[[1t44]] - hGLS/thymosin β-4 C-terminal fusion+rActin<br />
| |
| **[[1kcq]] – hGLS +Cd<br />
| |
| **[[1c0f]], [[1mdu]], [[1nmd]] - hGLS + Actin+Ca-ATP <br />
| |
| **[[1c0g]], [[1dej]] - hGLS +Actin (mutant)<br />
| |
| **[[3a5l]], [[3a5m]], [[3a5n]], [[3a5o]] - hGLS (mutant)+Actin (mutant)<br />
| |
| **[[3ci5]], [[3cip]], [[1nlv]] – DdGLS +actin - ''Dictyostelium discoideum''<br />
| |
| **[[1nm1]] - DdGLS +actin+Mg-ATP<br />
| |
| **[[3cjb]] - rGLS +rActin<br />
| |
| **[[3cjc]] - rGLS +rActin+DNAse I<br />
| |
| **[[4cbu]], [[4cbw]], [[4cbx]] - mGLS +actin+Ca+ATP<br />
| |
|
| |
|
| * GLS C-terminal
| | </StructureSection> |
|
| |
|
| **[[2fh1]], [[2fh2]], [[2fh3]], [[2fh4]] – hGLS <br />
| |
| **[[1p8x]] - hGLS +Ca<br />
| |
| **[[1p8z]] – hGLS fraction+rActin<br />
| |
| }}
| |
| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
