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| == Structural highlights == | | == Structural highlights == |
| ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/2'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/3'>Gly-Ser oxyanion hole</scene>. The <scene name='59/595760/Cv/4'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres. | | ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>. The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres. |
| </StructureSection>
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| == 3D Structures of matriptase == | | == 3D Structures of matriptase == |
| | [[Matriptase 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *'''matriptase'''
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| **[[4is5]] – hST14 catalytic domain - human<br />
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| *Matriptase complex with small molecule inhibitor
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| **[[1eax]] – hST14 catalytic domain + benzamidine <br />
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| **[[3p8g]] – hST14 residues 182-422 (mutant) + benzamidine <br />
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| **[[2gv6]] – hST14 catalytic domain + benzamidine derivative<br />
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| **[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br />
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| **[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br />
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| **[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]] – hST14 catalytic domain + inhibitor<br />
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| *Matriptase complex with polypeptide inhibitor
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| **[[1eaw]] – hST14 catalytic domain + BPTI<br />
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| **[[3bn9]] – hST14 catalytic domain + antibody<br />
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| **[[3nps]], [[3so3]] – hST14 catalytic domain (mutant) + antibody<br />
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| **[[3p8f]] – hST14 residues 182-422 (mutant) + trypsin inhibitor peptide <br />
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| **[[4isl]], [[4isn]], [[4iso]] – hST14 catalytic domain (mutant) + Kunitz-type protease inhibitor <br />
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| }}
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| == References == | | == References == |
