Neurexin: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry [[2xb6]])' scene='42/424006/Cv/2'> | ||
__TOC__ | __TOC__ | ||
== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
The surface interaction between NRXN and neuroligin is mediated by a Ca+2 ion<ref>PMID:20543817</ref>. | The <scene name='42/424006/Cv/7'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/8'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
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*Neurexin | *Neurexin | ||
**[[5z8y]] – hNRXN-1b + LRRTM2 – human<br /> | |||
**[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br /> | **[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br /> | ||
**[[3bod]], [[3bop]] - mNRXN- | **[[3bod]], [[3bop]] - mβNRXN-1 residues 1132-1246 + mb-NRXN-2 residues 1277-1334<br /> | ||
**[[ | **[[3mw4]] - mβNRXN-3 residues 854-1027<br /> | ||
**[[6pnp]], [[6pnq]] - mNRXN-1 LNS2 domain + neurexophilin-1<br /> | |||
**[[2r1b]], [[3mw3]] - rNRXN-1α LNS domain+splice insert 4 – rat<br /> | |||
**[[2r16]] - rNRXN-1α LNS domain+Ca<br /> | **[[2r16]] - rNRXN-1α LNS domain+Ca<br /> | ||
**[[1c4r]] - rNRXN-1α LNS domain<br /> | **[[1c4r]] - rNRXN-1α LNS domain<br /> | ||
**[[ | **[[2r1d]] - rNRXN-1β LNS/LG domain<br /> | ||
**[[2h0b]] - bNRXN-1α LNS2 domain – bovine<br /> | **[[2h0b]] - bNRXN-1α LNS2 domain – bovine<br /> | ||
**[[6cw1]] - bNRXN-1 LNS2-LNS3 domains<br /> | |||
**[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br /> | **[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br /> | ||
**[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br /> | **[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br /> | ||
**[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br /> | **[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br /> | ||
*NRXN+Neuroligin | *NRXN+Neuroligin | ||
**[[ | **[[2wqz]], [[2xb6]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br /> | ||
**[[3b3q]] - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br /> | **[[3b3q]] - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br /> | ||
**[[3biw]] - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br /> | **[[3biw]] - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br /> | ||
**[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain | **[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain | ||
**[[8g7y]], [[8g7z]], [[8g80]], [[8g81]] - mNRXN-1β + mNLGN-2 – Cryo EM | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:30, 24 March 2026
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3D Structures of Neurexin
24-March-2026
References
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman
