Neurexin: Difference between revisions

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<StructureSection load='2xb6' size='350' side='right' caption='Rat neurexin 1α LNS domain (deeppink) complex with neuroligin-4 cholinesterase domain (cyan) and Ca+2 ion (PDB entry [[2xb6]])' scene='42/424006/Cv/2'>
<StructureSection load='' size='350' side='right' caption='Glycosylated rat neurexin 1α LNS domain (cyan) complex with neuroligin-4 cholinesterase domain (pink), MES, ethylene glycol, Cl- and Ca+2 ions (PDB entry [[2xb6]])' scene='42/424006/Cv/2'>
__TOC__
__TOC__
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
The surface interaction between NRXN and neuroligin is mediated by a Ca+2 ion<ref>PMID:20543817</ref>.
The <scene name='42/424006/Cv/7'>surface interaction between NRXN and neuroligin</scene> is mediated by a <scene name='42/424006/Cv/8'>Ca+2 ion</scene><ref>PMID:20543817</ref>. Water molecules are shown as red spheres.


</StructureSection>
</StructureSection>
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*Neurexin
*Neurexin


**[[5z8y]] – hNRXN-1b + LRRTM2 – human<br />
**[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br />
**[[3mw2]] – mNRXN-1α LNS domain+splice insert 4 – mouse<br />
**[[3bod]], [[3bop]] -  mNRXN-1α LNS domain<br />
**[[3bod]], [[3bop]] -  mβNRXN-1 residues 1132-1246 + mb-NRXN-2 residues 1277-1334<br />
**[[3mw3]], [[2r1b]] - rNRXN-1α LNS domain+splice insert 4 – rat<br />
**[[3mw4]] -  mβNRXN-3 residues 854-1027<br />
**[[6pnp]], [[6pnq]] - mNRXN-1 LNS2 domain + neurexophilin-1<br />
**[[2r1b]], [[3mw3]] - rNRXN-1α LNS domain+splice insert 4 – rat<br />
**[[2r16]] - rNRXN-1α LNS domain+Ca<br />
**[[2r16]] - rNRXN-1α LNS domain+Ca<br />
**[[1c4r]] -  rNRXN-1α LNS domain<br />
**[[1c4r]] -  rNRXN-1α LNS domain<br />
**[[3mw4]] - mNRXN-1α LNS domain<br />
**[[2r1d]] - rNRXN-1β LNS/LG domain<br />
**[[2h0b]] -  bNRXN-1α LNS2 domain – bovine<br />
**[[2h0b]] -  bNRXN-1α LNS2 domain – bovine<br />
**[[6cw1]] - bNRXN-1 LNS2-LNS3 domains<br />
**[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br />
**[[3asi]] - bNRXN-1α LNS5-EGF3-LNS6 domains<br />
**[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br />
**[[3poy]] - bNRXN-1α LNS2-LNS6 domains (mutant)<br />
**[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br />
**[[3qcw]], [[3r05]] - bNRXN-1α LNS1-LNS6 domains (mutant)<br />
**[[2r1d]] - rNRXN-1β LNS/LG domain


*NRXN+Neuroligin       
*NRXN+Neuroligin       


**[[2xb6]], [[2wqz]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br />
**[[2wqz]], [[2xb6]] – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain<br />
**[[3b3q]] -  hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br />
**[[3b3q]] -  hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain<br />
**[[3biw]] -  rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br />
**[[3biw]] -  rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain<br />
**[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
**[[3vkf]] - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain
**[[8g7y]], [[8g7z]], [[8g80]], [[8g81]] - mNRXN-1β + mNLGN-2 – Cryo EM
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]
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