5j6x: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 5j6x is ON HOLD  until Paper Publication
==Crystal structure of the apo-Zalpha of Zebrafish PKZ==
<StructureSection load='5j6x' size='340' side='right'caption='[[5j6x]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5j6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J6X FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.493&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j6x OCA], [https://pdbe.org/5j6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j6x RCSB], [https://www.ebi.ac.uk/pdbsum/5j6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j6x ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q5NE12_DANRE Q5NE12_DANRE]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Z-DNA-binding domain of PKZ from zebrafish (Danio rerio; drZalphaPKZ ) contains the largest beta-wing among known Z-DNA-binding domains. To elucidate the functional implication of the beta-wing, we solved the crystal structure of apo-drZalphaPKZ . Structural comparison with its Z-DNA-bound form revealed a large conformational change within the beta-wing during Z-DNA binding. Biochemical studies of protein mutants revealed that two basic residues in the beta-wing are responsible for Z-DNA recognition as well as fast B-Z transition. Therefore, the extra basic residues in the beta-wing of drZalphaPKZ are necessary for the fast B-Z transition activity.


Authors:  
Structural and functional studies of a large winged Z-DNA-binding domain of Danio rerio protein kinase PKZ.,Subramani VK, Kim D, Yun K, Kim KK FEBS Lett. 2016 Jul;590(14):2275-85. doi: 10.1002/1873-3468.12238. Epub 2016 Jun , 23. PMID:27265117<ref>PMID:27265117</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 5j6x" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Danio rerio]]
[[Category: Large Structures]]
[[Category: Kim D]]
[[Category: Kim KK]]
[[Category: Subramani VK]]
Retrieved from "https://proteopedia.org/5j6x"