4bul: Difference between revisions
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==Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases== | ==Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases== | ||
<StructureSection load='4bul' size='340' side='right' caption='[[4bul]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='4bul' size='340' side='right'caption='[[4bul]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4bul]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4bul]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4BUL FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE8:(S)-4-((4-(((2,3-DIHYDRO-[1,4]DIOXINO[2,3-C]PYRIDIN-7-YL)METHYL)AMINO)PIPERIDIN-1-YL)METHYL)-3-FLUORO-4-HYDROXY-4H-PYRROLO[3,2,1-DE][1,5]NAPHTHYRIDIN-7(5H)-ONE'>AE8</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE8:(S)-4-((4-(((2,3-DIHYDRO-[1,4]DIOXINO[2,3-C]PYRIDIN-7-YL)METHYL)AMINO)PIPERIDIN-1-YL)METHYL)-3-FLUORO-4-HYDROXY-4H-PYRROLO[3,2,1-DE][1,5]NAPHTHYRIDIN-7(5H)-ONE'>AE8</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4bul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bul OCA], [https://pdbe.org/4bul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4bul RCSB], [https://www.ebi.ac.uk/pdbsum/4bul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4bul ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/GYRA_STAAN GYRA_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01897][https://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[Gyrase|Gyrase]] | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bax | [[Category: Staphylococcus aureus]] | ||
[[Category: Brooks | [[Category: Synthetic construct]] | ||
[[Category: Brown | [[Category: Bax B]] | ||
[[Category: Brown | [[Category: Brooks G]] | ||
[[Category: Cailleau | [[Category: Brown BS]] | ||
[[Category: Chen | [[Category: Brown P]] | ||
[[Category: Dabbs | [[Category: Cailleau N]] | ||
[[Category: Davies | [[Category: Chen D]] | ||
[[Category: Esken | [[Category: Dabbs S]] | ||
[[Category: Giordano | [[Category: Davies DT]] | ||
[[Category: Gwynn | [[Category: Esken JM]] | ||
[[Category: Hennessy | [[Category: Giordano I]] | ||
[[Category: Hoover | [[Category: Gwynn MN]] | ||
[[Category: Huang | [[Category: Hennessy AJ]] | ||
[[Category: Jones | [[Category: Hoover JL]] | ||
[[Category: Markwell | [[Category: Huang J]] | ||
[[Category: Miles | [[Category: Jones GE]] | ||
[[Category: Minthorn | [[Category: Markwell RE]] | ||
[[Category: Pearson | [[Category: Miles TJ]] | ||
[[Category: Rittenhouse | [[Category: Minthorn EA]] | ||
[[Category: Spitzfaden | [[Category: Pearson ND]] | ||
[[Category: Sukmar | [[Category: Rittenhouse S]] | ||
[[Category: Spitzfaden C]] | |||
[[Category: Sukmar SKK]] | |||
Latest revision as of 11:58, 20 December 2023
Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
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