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==Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex==
==Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex==
<StructureSection load='3quy' size='340' side='right' caption='[[3quy]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='3quy' size='340' side='right'caption='[[3quy]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3quy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUY FirstGlance]. <br>
<table><tr><td colspan='2'>[[3quy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUY:(2S,3R,4S,5R,6S)-6-[(2S,3S,4R)-2-(HEXACOSANOYLAMINO)-3,4-DIHYDROXY-OCTADECOXY]-3,4,5-TRIHYDROXY-N-(PHENYLMETHYL)OXANE-2-CARBOXAMIDE'>QUY</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3qux|3qux]], [[3quz|3quz]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=QUY:(2S,3R,4S,5R,6S)-6-[(2S,3S,4R)-2-(HEXACOSANOYLAMINO)-3,4-DIHYDROXY-OCTADECOXY]-3,4,5-TRIHYDROXY-N-(PHENYLMETHYL)OXANE-2-CARBOXAMIDE'>QUY</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cd1.1, CD1d, Cd1d1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), B2m, beta-2-microglobulin, mCG_11606, RP23-34E24.5-001 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3quy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3quy OCA], [https://pdbe.org/3quy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3quy RCSB], [https://www.ebi.ac.uk/pdbsum/3quy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3quy ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3quy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3quy OCA], [http://pdbe.org/3quy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3quy RCSB], [http://www.ebi.ac.uk/pdbsum/3quy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3quy ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD1D1_MOUSE CD1D1_MOUSE]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:11754812</ref> <ref>PMID:16314439</ref> <ref>PMID:16007091</ref>  [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.  
[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[CD1|CD1]]
*[[CD1|CD1]]
== References ==
== References ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Girardi, E]]
[[Category: Mus musculus]]
[[Category: Li, Y]]
[[Category: Girardi E]]
[[Category: Yu, E D]]
[[Category: Li Y]]
[[Category: Zajonc, D M]]
[[Category: Yu ED]]
[[Category: Antigen presentation]]
[[Category: Zajonc DM]]
[[Category: Glycolipid]]
[[Category: Immune system]]
[[Category: Nkt cell]]

Latest revision as of 08:07, 9 October 2024

Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex

3quy, resolution 2.25Å

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