4fk6: Difference between revisions
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==JAK1 kinase (JH1 domain) in complex with compound 72== | ==JAK1 kinase (JH1 domain) in complex with compound 72== | ||
<StructureSection load='4fk6' size='340' side='right' caption='[[4fk6]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4fk6' size='340' side='right'caption='[[4fk6]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4fk6]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4fk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FK6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0UJ:N-({1-[(1R,2R,4S)-BICYCLO[2.2.1]HEPT-2-YL]-1,6-DIHYDROIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-2-YL}METHYL)METHANESULFONAMIDE'>0UJ</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0UJ:N-({1-[(1R,2R,4S)-BICYCLO[2.2.1]HEPT-2-YL]-1,6-DIHYDROIMIDAZO[4,5-D]PYRROLO[2,3-B]PYRIDIN-2-YL}METHYL)METHANESULFONAMIDE'>0UJ</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fk6 OCA], [https://pdbe.org/4fk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fk6 RCSB], [https://www.ebi.ac.uk/pdbsum/4fk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fk6 ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 24: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[Janus kinase|Janus kinase]] | *[[Janus kinase 3D structures|Janus kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Eigenbrot | [[Category: Eigenbrot C]] | ||
[[Category: Steffek | [[Category: Steffek M]] | ||
Latest revision as of 08:20, 9 October 2024
JAK1 kinase (JH1 domain) in complex with compound 72
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