Semaphorin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (13 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='3nvn' size='350' side='right' scene='46/466531/Cv/2' caption='Glycosylated human semaphorin 7A (deeppink) complex with plexin-C1 (cyan) and Ca+2 ion (green), [[3nvn]]'> | |||
== Function == | == Function == | ||
'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. | '''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. SEMA and Plexin are crucial for the development and homeostasis of nervous, immune and cardiovascular systems. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics. | ||
*'''Semaphorin 3''' is needed for normal patterning and growth of nerves, bones and heart<ref>PMID:8849723</ref>.<br /> | *'''Semaphorin 3''' is needed for normal patterning and growth of nerves, bones and heart<ref>PMID:8849723</ref>.<br /> | ||
*'''Semaphorin 4D''' acts through its receptor to tip the balance of bone homeostasis toward resorption <ref>PMID:26910109</ref>.<br /> | *'''Semaphorin 4D''' acts through its receptor to tip the balance of bone homeostasis toward resorption <ref>PMID:26910109</ref>.<br /> | ||
*'''Semaphorin 6D''' is part of the complex involved in macrophage polarization <ref>PMID:29777213</ref>.<br /> | |||
*'''Semaphorin 7A''' promotes axon growth through integrins and MAPKs <ref>PMID:12879062</ref>.<br /> | *'''Semaphorin 7A''' promotes axon growth through integrins and MAPKs <ref>PMID:12879062</ref>.<br /> | ||
== Relevance == | == Relevance == | ||
SEMAs ar implicated in a number of developmental, psychiatric and neurodegenerative disorders<ref>PMID:19541473</ref>. SEMA 3A is a marker for disease activity of systemic lupus erythematosus<ref>PMID:22875653</ref>. | SEMAs ar implicated in a number of developmental, psychiatric and neurodegenerative disorders<ref>PMID:19541473</ref>. SEMA 3A is a marker for disease activity of systemic lupus erythematosus<ref>PMID:22875653</ref>. | ||
== Structural insights == | |||
SEMA interacts with plexin C1 via 3 regions: <scene name='46/466531/Cv/5'>SEMA extrusion helix</scene>, <scene name='46/466531/Cv/6'>loop4c-4d</scene> and <scene name='46/466531/Cv/7'>blade 3</scene><ref>PMID:20727575</ref>. Water molecules are shown as red spheres. | |||
==3D structures of semaphorin== | ==3D structures of semaphorin== | ||
[[Semaphorin 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
