Severin: Difference between revisions

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[[Image:Severin.png|left|200px|thumb|Crystal Structure of Human Severin, [[3fg6]]]]
<StructureSection load='1svy' size='350' side='right' scene='41/410299/Cv/6' caption='Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions [[1svy]]' pspeed='8'>
{{STRUCTURE_1svy| PDB=1svy |  SCENE= |CAPTION=Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions [[1svy]] }}


[[Severin]] is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin  and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins<ref>PMID:15060630</ref>. It is named Adseverin and Scinderin as well. 


[[Severin]] is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin  and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins<ref>PMID:15060630</ref>. It is named Adseverin and Scinderin as well.


*<scene name='41/410299/Cv/9'>Ca coordination site</scene>. Water molecules are shown as red spheres.
*<scene name='41/410299/Cv/10'>Na coordination site</scene>.
</StructureSection>


== 3D Structures of Severin ==
== 3D Structures of Severin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3fg6]] – Adseverin C-terminal – human<br />
[[3fg6]] – Adseverin C-terminal – human<br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />
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