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[[Image:1pft.gif|left|200px]]


{{Structure
==N-TERMINAL DOMAIN OF TFIIB, NMR==
|PDB= 1pft |SIZE=350|CAPTION= <scene name='initialview01'>1pft</scene>
<StructureSection load='1pft' size='340' side='right'caption='[[1pft]]' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
<table><tr><td colspan='2'>[[1pft]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PFT FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
|GENE= PYROCOCCUS FURIOSUS TFIIB GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pft OCA], [https://pdbe.org/1pft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pft RCSB], [https://www.ebi.ac.uk/pdbsum/1pft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pft ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pft OCA], [http://www.ebi.ac.uk/pdbsum/1pft PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pft RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TF2B_PYRFU TF2B_PYRFU] Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pf/1pft_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pft ConSurf].
<div style="clear:both"></div>


'''N-TERMINAL DOMAIN OF TFIIB, NMR'''
==See Also==
 
*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The three-dimensional structure of the N-terminal domain of an archaeal TFIIB, which has high sequence homology with eucaryal analogues, is strikingly similar to that of the C-terminal zinc ribbon of the eucaryal transcription elongation factor TFIIB.
[[Category: Large Structures]]
 
==About this Structure==
1PFT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFT OCA].
 
==Reference==
The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon., Zhu W, Zeng Q, Colangelo CM, Lewis M, Summers MF, Scott RA, Nat Struct Biol. 1996 Feb;3(2):122-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8564536 8564536]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Single protein]]
[[Category: Colangelo CM]]
[[Category: Colangelo, C M.]]
[[Category: Lewis LM]]
[[Category: Lewis, L M.]]
[[Category: Scott RA]]
[[Category: Scott, R A.]]
[[Category: Summers MF]]
[[Category: Summers, M F.]]
[[Category: Zeng Q]]
[[Category: Zeng, Q.]]
[[Category: Zhu W]]
[[Category: Zhu, W.]]
[[Category: n-terminal domain]]
[[Category: tfiib]]
[[Category: transcription initiation factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:59:05 2008''

Latest revision as of 05:55, 17 April 2024

N-TERMINAL DOMAIN OF TFIIB, NMR

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