5wry: Difference between revisions
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New page: '''Unreleased structure''' The entry 5wry is ON HOLD Authors: Cao, R., Wang, Y.L., Zhou, J., Huang, N., Xu, B.L. Description: Structure of human PARP1 catalytic domain bound to a quina... |
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==Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor== | |||
<StructureSection load='5wry' size='340' side='right'caption='[[5wry]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5wry]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WRY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4YR:N-[(3R)-1-(CYCLOPROPYLMETHYL)PYRROLIDIN-3-YL]-5-[(2,4-DIOXO-3,4-DIHYDROQUINAZOLIN-1(2H)-YL)METHYL]-2-FLUOROBENZAMIDE'>4YR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wry OCA], [https://pdbe.org/5wry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wry RCSB], [https://www.ebi.ac.uk/pdbsum/5wry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wry ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref> | |||
==See Also== | |||
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Xu | [[Category: Large Structures]] | ||
[[Category: Zhou | [[Category: Cao R]] | ||
[[Category: Huang N]] | |||
[[Category: Wang YL]] | |||
[[Category: Xu BL]] | |||
[[Category: Zhou J]] | |||
Latest revision as of 09:18, 20 March 2024
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
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