Poly(ADP-ribose) polymerase 3D structures

3D Structures of Poly (ADP-ribose) polymerase

Updated on 31-May-2026

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• Poly (ADP-ribose) polymerase 1; Domains – zinc finger 1 2-96; zinc finger 2 105-206; zinc finger 3 216-366; BRCT 389-487; WGR 517-642; ART 788-1012; catalytic 662-1101
  • 8g0h – hPARP 1 + DNA + drug – human
    
  • 3od8, 3oda, 9umc, 9umf – hPARP 1 zinc finger 1 + DNA
    
  • 1v9x, 2dmj - hPARP 1 zinc finger 1 - NMR
    
  • 3odc, 3ode - hPARP 1 zinc finger 2 + DNA
    
  • 2cs2, 2l30, 2l31 - hPARP 1 zinc finger 2 - NMR
    
  • 2riq - hPARP-1 zinc finger 3
    
  • 2jvn – hPARP 1 zinc finger 3 – NMR
    
  • 4av1 - hPARP-1 zinc fingers 1,2+ DNA
    
  • 2n8a - hPARP-1 zinc fingers 1,2+ DNA – NMR
    
  • 2cr9 - hPARP 1 WGR domain – NMR
    
  • 7aaa, 7kk2 – hPARP 1 catalytic domain
    
  • 2rcw, 4pjt - hPARP 1 α-helical and catalytic domain + inhibitor
    
  • 3gjw – hPARP 1 α-helical and catalytic domain (mutant) + inhibitor
    
  • 2cok – hPARP-1 C terminal (mutant) – NMR
    
  • 4dqy - hPARP-1 zinc fingers 1,3 and WGR domain + DNA
    
  • 3u9h – hPARP-1 catalytic domain + nicotinamide
    
  • 6bhv – hPARP 1 catalytic domain + NAD homolog
    
  • 1uk0, 1uk1, 1wok, 2rd6, 4gv7, 4hhy, 4hhz, 4r5w, 4r6e, 4rv6, 4und, 4uxb, 4zzz, 5a00, 5ds3, 5ha9, 5xsr, 5xst, 5xsu, 6i8t, 6vkk, 6vko, 6vkq, 6xvw, 7aab, 7onr, 7ons, 7ont, 8he7, 8jnz, 8vyh, 9etr, 9iln – hPARP-1 catalytic domain + inhibitor
    
  • 3gn7, 3l3l, 3l3m, 4l6s, 5kpn, 5kpo, 5kpp, 5kpq, 5wrq, 5wry, 5wrz, 5ws0, 5ws1, 5wtc, 6ghk – hPARP 1 catalytic domain (mutant) + inhibitor
    
  • 8u4w – hPARP-1 662-677, 788-1011 + inhibitor
    
  • 7kk3, 7kk4, 7kk5, 7kk6, 8hlr, 9etq – hPARP 1 catalytic domain + drug
    
  • 7aac, 7aad, 7cmw – hPARP 1 catalytic domain (mutant) + drug
    
  • 6nrf, 6nrg, 6nrh, 6nri, 6nrj, 6ntu – hPARP 1 ART domain + inhibitor
    
  • 9bpy – hPARP 1 ART domain + NAD analog
    
  • 9dmc – hPARP 1 ART domain + NAD analog + ADP-ribose
    
  • 8fyy, 8fyz, 8fz1 – hPARP 1 ART domain + inhibitor
    
  • 9mja – hPARP 1 ART domain + HPF1 + inhibitor – Cryo EM
    
  • 9mi8 – hPARP 1 1-1014 + DNA
    
  • 4xhu – hPARP 1 catalytic domain + protein homeless homolog
    
  • 4opx, 4oqa, 4oqb, 7s68, 7s6h, 7s6m, 7s81 – hPARP-1 zinc fingers 1,2,3, WGR and catalytic domain + DNA
    
  • 6m3i, 6nrf, 6nrg, 6nrh, 6nri, 6nrj, 6ntu – hPARP 1 ART domain + inhibitor
    
  • 7scy, 7scz - h PARP-1 BRCT domain in Nuc147 complex – Cryo EM
    
  • 2le0 - PARP-1 BRCT domain – rat - NMR
    
  • 6i8m, 6imt – cPARP-1 catalytic domain + inhibitor – chicken
    
• Poly (ADP-ribose) polymerase 2
  • 6x0l, 6x0m - hPARP 2 + HPF1 + DNA – Cryo EM
    
  • 6usj - hPARP 2 + nucleosome – Cryo EM
    
  • 6x0n - hPARP 2 + HPF1 + nucleosome – Cryo EM
    
  • 3kcz, 3kjd, 4tvj, 4zzx, 4zzy, 5dsy, 7r59, 8he8 - hPARP 2 catalytic domain + inhibitor
    
  • 8jny, 9im8 - hPARP 2 catalytic domain (mutant) + inhibitor
    
  • 8hkn - hPARP 2 catalytic domain + drug
    
  • 8hko, 8hks, 8hlj, 8hlq - hPARP 2 catalytic domain (mutant) + drug
    
  • 6tx3 - hPARP 2 catalytic domain + HPF1
    
  • 4pjv - hPARP 2 α helical and catalytic domain + inhibitor
    
  • 6f1k, 6f5b, 6f5f - hPARP 2 WGR domain + DNA
    
  • 9zq9, 9zqa - hPARP 2 WGR domain + nucleosome – Cryo EM
    
  • 9zqb, 9zqc - hPARP 2 WGR domain + HPF1 + nucleosome – Cryo EM
    
  • 7aeb - hPARP 2 90-583 + DNA
    
  • 5d5k - hPARP 2 residues 1-78 + importin subunit -1
    
  • 1gs0 - mPARP 2 catalytic domain - mouse
• Poly (ADP-ribose) polymerase 3
  • 2eoc – hPARP-3 WGR domain – NMR
    
  • 3c49, 3c4h, 3ce0, 3fhb, 4gv0, 4gv2, 4gv4, 4l6z, 4l70, 4l7l, 4l7n 4l7o, 4l7p, 4l7r, 4l7u - hPARP-3 catalytic domain + inhibitor
• Poly (ADP-ribose) polymerase 4;Domains – BRCT 1-100; ART 242-282, 365-573; catalytic 242-573
  • 11jf – hPARP-4 + major vault protein – Cryo EM
    
  • 8swy – hPARP-4 ART domain 242-282, 365-573 + NAD
    
  • 8swz – hPARP-4 ART domain + inhibitor
    
  • 9dev – hPARP-4 BRCT domain
    
  • 9dfo, 9dfp, 9dfq, 9dfr – hPARP-4 BRCT domain (mutant)
    
  • 8sx1 – hPARP-4 catalytic domain
    
  • 8sx2 – hPARP-4 catalytic domain + inhibitor
    
  • 9bw6 – hPARP-4 in vault cage complex – Cryo EM
    
• Poly (ADP-ribose) polymerase 5
  • 8x5j – hPARP-5A
    
• Poly (ADP-ribose) polymerase 9
  • 9qyd – hPARP-9 macrodomain 1 102-300
    
  • 9qye – hPARP-9 macrodomain 1 + ADP-ribose
    
  • 5ail, 9qyg – hPARP-9 macrodomain 2 310-493
    
  • 9qyf – hPARP-9 macrodomain 2 + ADP-ribose
    
  • 9qyh – hPARP-9 macrodomain 2 + NAD
    
• Poly (ADP-ribose) polymerase 10
  • 5lx6, 9rls - hPARP 10 catalytic domain + inhibitor
    
  • 3hkv - hPARP 10 catalytic domain (mutant) + inhibitor
    
  • 6fxi - hPARP-10 catalytic domain + aminobenzamide
    
  • 2dhx - hPARP 10 RRM domain
  • 9frp, 9frs - hPARP 10 ART domain + inhibitor
    
• Poly (ADP-ribose) polymerase 11
  • 2dk6 - hPARP 11 WWE domain – NMR
    
• Poly (ADP-ribose) polymerase 12
  • 8xpx - hPARP-12 catalytic domain 489-684
    
  • 2pqf - hPARP-12 catalytic domain + inhibitor
    
  • 6v3w - hPARP-12 catalytic domain (mutant) + inhibitor
    
• PARP 13 or ZAP or Zinc finger CCCH-type antiviral protein 1; Domains – RBD 1-227; catalytic 498-699
  • 6uei – hPARP-13 RBD domain
    
  • 6uej – hPARP-13 RBD domain + RNA
    
  • 9bgl – hPARP-13 RBD domain + KHNYN
    
  • 7kzh – hPARP-13 catalytic domain
    
  • 7tgq – hPARP-13 catalytic domain + ADP-ribose
    
  • 7sz3 – mPARP-13 592-789 + ADPr
    
  • 7sz2 – mPARP-13 592-789 + ATP
    
  • 6l1w – mPARP-13 RBD domain + RNA
    
• Poly (ADP-ribose) polymerase 14; Domains – WWE 139-224; macro 1 708-898; macro 2 918-1115; macro 3 1208-1388; catalytic 1611-1801
  • 3goy, 3se2, 3smi, 3smj, 4f1l, 4f1q, 4py4, 5lxp, 5lyh, 5nqe, 5v7t, 5v7w, 6fym, 6fzm, 6g0w, 6we2, 6we3, 6we4, 7l9y, 7lun, 7r3l - hPARP 14 catalytic domain + inhibitor
    
  • 3q6z - hPARP-14 macro domain 1+ ADPR
    
  • 3q71 - hPARP-14 macro domain 2+ ADPR
    
  • 5o2d - hPARP-14 macro domain 2 (mutant) + inhibitor
    
  • 3vfq, 4d86 - hPARP-14 macro domain 1+2 + ADPR
    
  • 4abl, 7d2c - hPARP-14 macro domain 3
    
  • 4abk - hPARP-14 macro domain 3+ ADPR
    
  • 5qht, 5qhu, 5qhv, 5qhw, 5qhx, 5qhy, 5qhz, 5qi0, 5qi1, 5qi2, 5qi3, 5qi4, 5qi5, 5qi6, 5qi7, 5qi8, 5qi9, 5qia - hPARP-14 macro domain 3 + inhibitor
    
  • 1x4r - mPARP-14 WWE domain – NMR
    
• Poly (ADP-ribose) polymerase 15
  • 3blj - hPARP-15 catalytic domain
    
  • 4f0e - hPARP-15 catalytic domain + ligand
    
  • 3gey, 6ry4, 7oqq, 7osp, 7oss, 7osx, 7otf, 7oth, 7ouw, 7oux, 7pw3, 7pwa, 7pwc, 7pwk, 7pwl, 7pwm, 7pwq, 7pwp, 7pwr, 7pws, 7pwu, 7pww, 7px6, 7px7, 7r3o, 7r4a, 7r5d, 7z1v, 7z1w, 7z1y, 7z20, 7z2q, 7z41, 8zv7, 9feg, 9rlo, 9rlp, 9rlq, 9rlr, 9tcb - hPARP-15 catalytic domain + inhibitor
    
  • 7f41, 7f42, 7f43 – hPARP-15 catalytic domain + drug
    
  • 6ek3, 9ifv - hPARP-15 catalytic domain (mutant) + inhibitor
    
  • 3v2b – hPARP-15 macro domain 2 + ADP
    
• Poly (ADP-ribose) polymerase 16 residues 5-279
  • 4f0d - hPARP-16 + aminobenzamide
    
  • 6hxr, 6w65 - hPARP-16 + inhibitor
    
  • 6hxs - hPARP-16 + CABRA-NAD
    
• Poly (ADP-ribose) polymerase
  • 1a26 – cPARP catalytic domain +carba-NAD – chicken
    
  • 2paw - cPARP catalytic domain
    
  • 1efy, 1pax, 2pax, 3pax, 4pax - cPARP catalytic domain + inhibitor
    
  • 5ngo – AtPARP Rcd1 PARP domain residues 269-460 – Arabidopsis thaliana
    
  • 5n9q – AtPARP Rcd1 residues 468-567
    
• Tankyrase 1 or PARP 5a (SAM domain 1018-1093; catalytic domain 1093-1325)
  • 5jti, 5ju5, 5kni - hTank 1 SAM domain
    
  • 2rf5 - hTank 1 catalytic domain (mutant)
    
  • 3udd, 3uh2, 3uh4, 4dvi, 4i9i, 4k4e, 4k4f, 4krs, 4li6, 4li7, 4li8, 4msg, 4msk, 4mt9, 4n3r, 4n4v, 4oa7, 4tor, 4u6a, 4uuh, 4uw1, 4w5s, 4w6e, 5ebt, 5ece, 6qxu - hTank 1 catalytic domain + inhibitor
    
  • 7kkm, 7kkn, 7kko, 7kkp, 7kkq - hTank 1 catalytic domain + drug
    
  • 4tos, 5ety - hTank 1 catalytic domain (mutant) + inhibitor
    
  • 5gp7 - hTank 1 residues 799-957 + USP25
    
  • 5jhq - hTank 1 residues 174-649 + peptide
    
  • 6uro, 6urq - hTank 1 residues 328-646 + PAGE-4
    
  • 6cf6 - mTank 1 residues 308-655 + RNF146
    
• Tankyrase 2 or PARP 5b (Domains: ARC4 488-649; SAM 867-940; catalytic 946-1113; C-terminal 1114-1162)
  • 5jrt - hTank 2 SAM domain
    
  • 9qfc - hTank 2 ARC4 domain + inhibitor
    
  • 9qjz - hTank 2 ARC4 domain + MDC1 peptide
    
  • 3twq - hTank 2 residues 484-655
    
  • 3twr, 3tws, 3twt, 3twu, 3twv, 3tww, 3twx, 4z68, 5bxo, 5bxu - hTank 2 residues 484-655 + peptide substrate
    
  • 3kr7 - hTank 2 catalytic domain
    
  • 4hki - hTank 2 catalytic + C terminal domains
    
  • 8aly - hTank 2 SAM + catalytic domains – Cryo EM
    
  • 3kr8, 3mhk, 3mhj, 3p0n, 3p0p, 3p0q, 3u9y, 3ua9, 3w51, 4avu, 4avw, 4bfp, 4bj9, 4bjb, 4bjc, 4bs4, 4bu3, 4bu5, 4bu6, 4bu7, 4bu8, 4bu9, 4bua, 4bud, 4bue, 4buf, 4bui, 4bus, 4but, 4buu, 4buv, 4buw, 4bux, 4buy, 4hyf, 4iue, 4j1z, 4j21, 4j22, 4j3l, 4j3m, 4m7b, 4pml, 4pnl, 4pnm, 4pnn, 4pnq, 4pnr, 4pns, 4pnt, 4tju, 4tjw, 4tjy, 4tk0, 4tk5, 4tkf, 4tkg, 4tki, 4ufu, 4uhg, 4ui3, 4ui4, 4ui5, 4ui6, 4ui7, 4ui8, 4uvl, 4uvn, 4uvo, 4uvp, 4uvs, 4uvt, 4uvu, 4uvv, 4uvw, 4uvx, 4uvy, 4uvz, 4ux4, 4w5i, 5adq, 5adr, 5ads, 5adt, 5aeh, 5aku, 5akw, 5al1, 5al2, 5al3, 5al4, 5al5, 5ows, 5owt, 6tg4, 6tkm, 6tkn, 6tkp, 6tkq, 6tkr, 6tks, 7ce4, 7o6x, 7ojo, 7olj, 7om1, 7omc, 7pox, 7r3z, 7r5x, 8s4v, 8s4w, 8s4x, 8s60, 9rqq, 9rrp - hTank 2 catalytic domain+ inhibitor
    
  • 7ocv - hTank 2 SAM + catalytic domains + inhibitor
    
  • 4hkk, 4hkn, 4hl5, 4hlf, 4hlg, 4hlh, 4hlk, 4hlm, 4hmh, 4kzl, 4kzq, 4kzu, 4l09, 4l0b, 4l0i, 4l0s, 4l0t, 4l0v, 4l10, 4l2f, 4l2g, 4l2k, 4l31, 4l32, 4l33, 4l34, 4ufy, 5c5p, 5c5q, 5c5r, 5dcz, 5fpf, 5fpg, 5nwg, 5nwd, 5nwc, 5nwb 5nvh, 5nvf, 5nve, 5nvc, 5nut, 5nt4, 5nt0, 5nsx, 5nsp, 5nob, 5nxe, 5zqo, 5zqp, 5zqq, 5zqr, 6a84, 6kro, 8b6m - hTank 2 catalytic and C terminal domains + inhibitor
    
  • 8w2t, 8w2u - hTank 2 SAM and catalytic domains – Cryo EM
    

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