ERGIC-53: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' caption='Human ERGIC-53 carbohydrate recognition domain complex with mannose (stick model), glycerol and Ca+2 ion (green) (PDB code [[4gky]])' scene='74/748868/Cv/1'> | ||
== Function == | == Function == | ||
'''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. | '''ER-Golgi Intermediate Compartment-53 (ERGIC-53)''' is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi<ref>PMID:19609866</ref>. | ||
== Relevance == | == Relevance == | ||
Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well<ref>PMID:23709226</ref>. | ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/3'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>. Water molecules are shown as red spheres. | ||
</StructureSection> | </StructureSection> | ||
==3D structures of ERGIC-53== | ==3D structures of ERGIC-53== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
ERGIC-53; Domains – CRD 31-269 | |||
[[4ygb]], [[4ygc]], [[4ygd]], [[4yge]], [[3wht]], [[3lcp]], [[3a4u]] – hERGIC-53 CRD domain + MCFD2 + Ca | [[8jp4]], [[8jp5]], [[8jp6]], [[8jp7]], [[8jp8]], [[8jp9]], [[8jpg]] – hERGIC-53 + MCFD2 + Ca - human - Cryo EM<br /> | ||
[[4ygb]], [[4ygc]], [[4ygd]], [[4yge]], [[3wht]], [[3lcp]], [[3a4u]] – hERGIC-53 CRD domain + MCFD2 + Ca<br /> | |||
[[3whu]], [[3wnx]] – hERGIC-53 CRD domain + MCFD2 + Ca + mannose<br /> | [[3whu]], [[3wnx]] – hERGIC-53 CRD domain + MCFD2 + Ca + mannose<br /> | ||
[[4gkx]] – hERGIC-53 CRD domain + Ca <br /> | [[4gkx]] – hERGIC-53 CRD domain + Ca <br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
Latest revision as of 07:12, 3 June 2025
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3D structures of ERGIC-53
Updated on 03-June-2025
ERGIC-53; Domains – CRD 31-269
8jp4, 8jp5, 8jp6, 8jp7, 8jp8, 8jp9, 8jpg – hERGIC-53 + MCFD2 + Ca - human - Cryo EM
4ygb, 4ygc, 4ygd, 4yge, 3wht, 3lcp, 3a4u – hERGIC-53 CRD domain + MCFD2 + Ca
3whu, 3wnx – hERGIC-53 CRD domain + MCFD2 + Ca + mannose
4gkx – hERGIC-53 CRD domain + Ca
4gky – hERGIC-53 CRD domain + Ca + mannose
1r1z – rERGIC-53 CRD domain + Ca - rat
1gv9 – rERGIC-53 CRD domain
