Nucleolin: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='450' side='right' caption='Hamster nucleolin RNA recognition motifs 1-2 (blue) complex with RNA (green) (PDB code [[1rkj]])' scene='74/749425/Cv/1'> | ||
== Function == | == Function == | ||
Nucleolin (NCL) is a multifunctional phosphoprotein found in the nucleolus, nucleus and cytoplasm. NCL contains intrinsic DNA and RNA helicase, nucleic-acid-dependent ATPase and self-cleaving activities. NCL binds RNA through its RNA recognition motifs (RBD). It regulates various aspects of DNA and RNA metabolism<ref>PMID:21980556</ref>. | '''Nucleolin''' (NCL) is a multifunctional phosphoprotein found in the nucleolus, nucleus and cytoplasm. NCL contains intrinsic DNA and RNA helicase, nucleic-acid-dependent ATPase and self-cleaving activities. NCL binds RNA through its RNA recognition motifs (RBD). It regulates various aspects of DNA and RNA metabolism<ref>PMID:21980556</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
The RNA loop is sandwiched between RBD 1 and 2 interacting with both NCL domains<ref>PMID:15033352</ref>. | The <scene name='74/749425/Cv/6'>RNA loop is sandwiched between RBD 1 and 2</scene> interacting with both NCL domains<ref>PMID:15033352</ref>. <scene name='74/749425/Cv/7'>RNA-protein interactions</scene>. | ||
</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[2krr]] – hNCL RBD1-2 | [[9cb5]] – hNCL + antibody + DNA – human <br /> | ||
[[2krr]] – hNCL RBD1-2 - NMR<br /> | |||
[[2fc8]], [[2fc9]] – hNCL RRM_1 domain - NMR <br /> | [[2fc8]], [[2fc9]] – hNCL RRM_1 domain - NMR <br /> | ||
[[1rkj]], [[1fje]] – haNCL RBD1-2 + RNA – hamster - NMR<br /> | [[1rkj]], [[1fje]] – haNCL RBD1-2 + RNA – hamster - NMR<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
