Apoptosis-inducing factor: Difference between revisions

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<StructureSection load='4bur' size='450' side='right' caption='Human apoptosis-inducing factor complex with FAD, NAD and sulfate (PDB code [[4bur]])' scene='74/749463/Cv/1'>
<StructureSection load='' size='450' side='right' caption='Human apoptosis-inducing factor complex with FAD, NAD and sulfate (PDB code [[4bur]])' scene='74/749463/Cv/1'>


== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
The AIF binding site contains the cofactor FAD and 2 molecules of the reducing factor NADH<ref>PMID:24914854</ref>.
The AIF binding site contains the cofactor <scene name='74/749463/Cv/2'>FAD</scene> and 2 molecules of the reducing factor NADH<ref>PMID:24914854</ref>. Water molecules shown as red spheres.
*<scene name='74/749463/Cv/3'>1st NADH binding site</scene>.
*<scene name='74/749463/Cv/4'>2nd NADH binding site</scene>.
*<scene name='74/749463/Cv/5'>FAD/1st molecule NADF tunnel</scene>.
*<scene name='74/749463/Cv/6'>2nd NADH binding site in surface representation</scene>.


</StructureSection>
</StructureSection>
==3D structures of apoptosis-inducing factor==
==3D structures of apoptosis-inducing factor see CED-8 in [[Cell death protein]]==
 
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
[[4bv6]], [[4lii]], [[1m6i]] – hAIF – human <br />
[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hAIF (mutant)  <br />
[[4bur]] – hAIF + NAD <br />
[[3gd3]], [[1gv4]] – mAIF – mouse <br />
[[3gd4]] – mAIF + NAD <br />




== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]

Latest revision as of 09:56, 15 March 2018

Human apoptosis-inducing factor complex with FAD, NAD and sulfate (PDB code 4bur)

Drag the structure with the mouse to rotate

3D structures of apoptosis-inducing factor see CED-8 in Cell death protein

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman