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[[Image:1si7.jpg|left|200px]]


{{Structure
==Structure of E. coli tRNA psi 13 pseudouridine synthase TruD==
|PDB= 1si7 |SIZE=350|CAPTION= <scene name='initialview01'>1si7</scene>, resolution 2.20&Aring;
<StructureSection load='1si7' size='340' side='right'caption='[[1si7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1si7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SI7 FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pseudouridylate_synthase Pseudouridylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.70 4.2.1.70] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
|GENE= TRUD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1si7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1si7 OCA], [https://pdbe.org/1si7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1si7 RCSB], [https://www.ebi.ac.uk/pdbsum/1si7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1si7 ProSAT]</span></td></tr>
|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02575 PseudoU_synth_EcTruD], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd02552 PseudoU_synth_TruD_like], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=PRK00984 truD]</span>
</table>
|RELATEDENTRY=
== Function ==
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1si7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1si7 OCA], [http://www.ebi.ac.uk/pdbsum/1si7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1si7 RCSB]</span>
[https://www.uniprot.org/uniprot/TRUD_ECOLI TRUD_ECOLI] Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.<ref>PMID:12756329</ref>
}}
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/si/1si7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1si7 ConSurf].
<div style="clear:both"></div>


'''Structure of E. coli tRNA psi 13 pseudouridine synthase TruD'''
==See Also==
 
*[[Guide-independent Pseudouridine synthase|Guide-independent Pseudouridine synthase]]
 
*[[Pseudouridine synthase 3D structures|Pseudouridine synthase 3D structures]]
==Overview==
== References ==
TruD, a recently discovered novel pseudouridine synthase in Escherichia coli, is responsible for modifying uridine13 in tRNA(Glu) to pseudouridine. It has little sequence homology with the other 10 pseudouridine synthases in E. coli which themselves have been grouped into four related protein families. Crystal structure determination of TruD revealed a two domain structure consisting of a catalytic domain that differs in sequence but is structurally very similar to the catalytic domain of other pseudouridine synthases and a second large domain (149 amino acids, 43% of total) with a novel alpha/beta fold that up to now has not been found in any other protein.
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
1SI7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SI7 OCA].
 
==Reference==
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold., Kaya Y, Del Campo M, Ofengand J, Malhotra A, J Biol Chem. 2004 Apr 30;279(18):18107-10. Epub 2004 Mar 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14999002 14999002]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Pseudouridylate synthase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Del Campo M]]
[[Category: Campo, M Del.]]
[[Category: Kaya Y]]
[[Category: Kaya, Y.]]
[[Category: Malhotra A]]
[[Category: Malhotra, A.]]
[[Category: Ofengand J]]
[[Category: Ofengand, J.]]
[[Category: novel fold]]
[[Category: pseudouridine synthase]]
[[Category: trna]]
[[Category: trud]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:25 2008''

Latest revision as of 08:30, 14 February 2024

Structure of E. coli tRNA psi 13 pseudouridine synthase TruD

1si7, resolution 2.20Å

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