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==Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)==
==Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)==
<StructureSection load='4qaf' size='340' side='right' caption='[[4qaf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4qaf' size='340' side='right'caption='[[4qaf]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4qaf]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QAF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4qaf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QAF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OMA:10-{(1R,2R)-2-[(2E)-HEX-2-EN-1-YL]CYCLOPROPYL}DECANOIC+ACID'>OMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qaf OCA], [http://pdbe.org/4qaf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qaf RCSB], [http://www.ebi.ac.uk/pdbsum/4qaf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qaf ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OMA:10-{(1R,2R)-2-[(2E)-HEX-2-EN-1-YL]CYCLOPROPYL}DECANOIC+ACID'>OMA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qaf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qaf OCA], [https://pdbe.org/4qaf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qaf RCSB], [https://www.ebi.ac.uk/pdbsum/4qaf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qaf ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1) [MIM:[http://omim.org/entry/603933 603933]]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LCN1_HUMAN LCN1_HUMAN]] Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket. [[http://www.uniprot.org/uniprot/VEGFA_HUMAN VEGFA_HUMAN]] Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.<ref>PMID:11427521</ref> <ref>PMID:15520188</ref> <ref>PMID:16489009</ref> 
[https://www.uniprot.org/uniprot/LCN1_HUMAN LCN1_HUMAN] Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.


==See Also==
==See Also==
*[[Neutrophil gelatinase-associated lipocalin|Neutrophil gelatinase-associated lipocalin]]
*[[Neutrophil gelatinase-associated lipocalin|Neutrophil gelatinase-associated lipocalin]]
*[[Vascular Endothelial Growth Factor|Vascular Endothelial Growth Factor]]
*[[VEGF 3D Structures|VEGF 3D Structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Giese, T]]
[[Category: Homo sapiens]]
[[Category: Skerra, A]]
[[Category: Large Structures]]
[[Category: Beta-barrel]]
[[Category: Giese T]]
[[Category: Binding protein]]
[[Category: Skerra A]]
[[Category: Engineered lipocalin]]
[[Category: Transport protein-signaling protein complex]]

Latest revision as of 17:30, 20 September 2023

Crystal structure of an engineered lipocalin (Anticalin) in complex with VEGF(8-109)

4qaf, resolution 1.80Å

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