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==Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex==
==Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex==
<StructureSection load='5t5w' size='340' side='right' caption='[[5t5w]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='5t5w' size='340' side='right'caption='[[5t5w]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5t5w]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T5W FirstGlance]. <br>
<table><tr><td colspan='2'>[[5t5w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T5W FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.847&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5w OCA], [http://pdbe.org/5t5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t5w RCSB], [http://www.ebi.ac.uk/pdbsum/5t5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5w ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t5w OCA], [https://pdbe.org/5t5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t5w RCSB], [https://www.ebi.ac.uk/pdbsum/5t5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t5w ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/I10R2_HUMAN I10R2_HUMAN]] Autosomal recessive early-onset inflammatory bowel disease. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/IFNL3_HUMAN IFNL3_HUMAN]] Response to antiviral treatment in hepatitis C. 
[https://www.uniprot.org/uniprot/I10R2_HUMAN I10R2_HUMAN] Autosomal recessive early-onset inflammatory bowel disease. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/I10R2_HUMAN I10R2_HUMAN]] Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.<ref>PMID:12469119</ref> <ref>PMID:15123776</ref> [[http://www.uniprot.org/uniprot/IFNL3_HUMAN IFNL3_HUMAN]] Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.<ref>PMID:12469119</ref> <ref>PMID:12483210</ref>  [[http://www.uniprot.org/uniprot/INLR1_HUMAN INLR1_HUMAN]] The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<ref>PMID:12521379</ref> <ref>PMID:12469119</ref> <ref>PMID:12483210</ref> 
[https://www.uniprot.org/uniprot/I10R2_HUMAN I10R2_HUMAN] Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.<ref>PMID:12469119</ref> <ref>PMID:15123776</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5t5w" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5t5w" style="background-color:#fffaf0;"></div>
==See Also==
*[[Interferon 3D structures|Interferon 3D structures]]
*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
*[[Interleukin 3D structures|Interleukin 3D structures]]
*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Garcia, K C]]
[[Category: Homo sapiens]]
[[Category: Jude, K M]]
[[Category: Large Structures]]
[[Category: Mendoza, J L]]
[[Category: Garcia KC]]
[[Category: Cytokine]]
[[Category: Jude KM]]
[[Category: Cytokine-cytokine receptor complex]]
[[Category: Mendoza JL]]
[[Category: Receptor]]

Latest revision as of 12:55, 4 October 2023

Structure of an affinity matured lambda-IFN/IFN-lambdaR1/IL-10Rbeta receptor complex

5t5w, resolution 2.85Å

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