Interleukin receptor 3D structures

3D structures of interleukin receptor

Updated on 05-October-2025

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• Interleukin receptor type I
• Interleukin-1 receptor
  • 4gaf – hIL1R + EBI-005 - human
    
  • 1g0y – hIL1R + peptide
    
  • 4dep - hIL1R + hIL1 β + IL1 receptor accessory protein
    
• Interleukin-2 receptor
  • 1z92 – hIL2R α subunit + IL2
    
  • 3iu3, 3nfp - hIL2R α subunit + antibody
  • 5m5e - hIL2R β + gamma subunits + IL2
    
  • 2b5i - hIL2R α+β+γ subunits + IL2
    
  • 3qaz, 6dg5 - hIL2R β+γ subunits + IL2
    
  • 2erj - hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)
    
  • 3qb7 - hIL2R γ (mutant) subunit + IL2
    
  • 8epa, 9jqt - hIL2R γ subunit + antibody – Cryo EM
    
• Interleukin-3 receptor
  • 4jzj – hIL3R α subunit + antibody
    
  • 5uv8, 5uwc – hIL3R α subunit (mutant) + IL3
    
  • 6nmy – hIL3R α subunit (mutant) + beta subunit + IL3 + cytokine receptor common subunit b
    
  • 4qqv - mIL6R β subunit (mutant) - mouse
    
• Interleukin-4 receptor
  • 1iar - hIL4R α (mutant) subunit + IL4
    
  • 3bpl - hIL4R α + γ subunits + IL4
    
  • 3bpn - hIL4R α subunit + hIL13R α subunit + IL4
    
  • 3bpo - hIL4R α subunit + hIL13R α subunit + IL13
    
  • 8k4q, 8z8l - hIL4R α subunit + nanobody
    
  • 6oel - hIL4R α subunit + hIL2R gamma subunit + IL4 + antibody
    
• Interleukin-5 receptor
  • 3qt2 – hIL5R α (mutant) subunit + IL5
    
  • 3va2 - hIL5R α subunit + IL5
    
  • 6h41 - hIL5R α subunit + peptide ihibitor
    
  • 8tld - hIL5R α + beta subunits + IL5 – Cryo EM
    
• Interleukin-6 receptor or gp130
  • 1i1r – hIL6R β subunit + IL6 homolog
    
  • 1pvh - hIL6R β subunit + leukemia inhILbitory factor
    
  • 3l5i, 3l5j, 3l5h - hIL6R β subunit
    
  • 1n26 - hIL6R α subunit
    
  • 2arw - hIL6R α subunit - NMR
    
  • 1p9m - hIL6R α + β subunits + IL6
    
  • 8upa – hIL6R β 124-321 + sIL-6 1-56 – synthetic
    
  • 7dc8 – hIL6R α subunit + antibody
    
  • 8iow, 8j6f – hIL6R α subunit + antibody – Cryo EM
    
  • 8d7r – hIL6R beta subunit in CLCF1 complex – Cryo EM
    
  • 8d74 – hIL6R beta subunit in CNTF signaling complex – Cryo EM
    
  • 8v2b, 8v2c – hIL6R beta subunit + oncostatin + oncostatin-specific receptor beta subunit – Cryo EM
    
  • 8v2a – hIL6R beta subunit + oncostatin + LIFR - Cryo EM
    
  • 8d6a – hIL6R beta subunit + LIF + LIFR - Cryo EM
    
  • 5fuc - mI6R α subunit + IL6 +VHH6
    
  • 2hmh - mI6R β subunit + suppressor of cytokine signaling 3
    
  • 4gl9 - mI6R β subunit + suppressor of cytokine signaling 3 + tyrosine-protein kinase
    
• Interleukin-7 receptor
  • 3up1 - hIL7R α subunit
    
  • 3di2, 3di3 – hIL7R α (mutant) subunit + IL7 (mutant)
    
  • 6p50, 6p67 - hIL7R α subunit + antibody
    
  • 4nn5, 4nn6, 4nn7, 5j12, 5j11 - mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2
    
  • 8ddc – mIL7R alpha subunit transmembrane domain + mIL2R gamma subunit transmembrane domain - NMR
    
• Interleukin-9 receptor
  • 8ddd – mIL9R transmembrane domain + mIL2R gamma subunit transmembrane domain - NMR
    
• Interleukin-10 receptor
  • 5t5w - hIL10 (mutant) + interferon λ receptor 21 + interferon λ-3 subunit
    
• Interleukin-11 receptor
  • 6o4p – hIL11R α subunit
    
  • 8dpu - hIL11R alpha+beta + IL-11
    
  • 8dpt - hILR11 alpha (mutant) + hILR6 + hIL11– Cryo EM
    
• Interleukin-12 receptor
  • 8c7m, 8odx - hIL13R beta1 subunit FN domains + antibody
    
  • 8pb1, 8yi7 - hIL12R α and β + hIL12 α and β – Cryo EM
    
  • 8oe0, 8xrp - hIL12R beta1 and beta2 + hIL12 α and β – Cryo EM
    
  • 8oe4 - hIL12R α and β + hIL12 α and β + hIL23R α and β + hIL23 α and β – Cryo EM
    
• Interleukin-13 receptor
  • 3lb6 - hIL13R α2 (mutant) subunit + IL13
    
  • 4hwb - hIL13R α1 subunit + antibody
    
  • 5e4e - hIL13R α1 subunit + IL4R α subunit + IL13
    
• Interleukin-15 receptor
  • 2ers - hIL15R α subunit sushIL domain – NMR
    
  • 2psm, 2z3q, 2z3r - hIL15R α subunit + IL15
    
  • 4gs7 - hIL15R α subunit + IL15 + hIL2R β,γ subunits
    
• Interleukin-17 receptor
  • 4nux - hIL17RA SEFIR domain
    
  • 5n9b - hIL17RA extracellular domain
    
  • 3jvf - hIL17RA extracellular domain + IL17F
    
  • 5nan - hIL17RA + IL17A + IL17F
    
  • 4hsa - hIL17RA (mutant) + IL17A
    
  • 6hg4, 6hg9 - hIL17RC (mutant) + IL17F
    
  • 6hga - hIL17RC D2-D4 domains (mutant) + antibody
    
  • 3vbc – mIL17RB
    
• Interleukin-18 receptor
  • 3wo3, 4r6u - hIL18 receptor + hIL18
    
  • 3wo4 - hIL18 receptor + hIL18 + IL18 receptor accessory protein
    
• Interleukin-21 receptor
  • 4nzd – hIL21R
    
  • 3tgx – hIL21R extracellular domain (mutant) + IL21
    
  • 7kq7 – hIL21R + antibody
    
  • 9e2t - ILR21 + ILR2 gamma + hIL21 (mutant)
    
  • 8ent - hIL21R (mutant) + IL2R gamma (mutant) + hIL21 (mutant)
    
• Interleukin-23 receptor
  • 5mzv – hIL23R + IL12 + IL23 + nanobody
    
  • 9mfg – hIL23R + VHH
    
• Interleukin-31 receptor
  • 9eza – hIL31R D1D2 domain + scFv
    
• Interleukin receptor type II
• Interleukin-10 receptor
  • 1j7v – hIL10R α (mutant) subunit + IL10
    
  • 1lqs, 1y6m, 1y6n - hIL10R α (mutant) subunit + IL10 homolog
    
  • 1y6k- hIL10R α (mutant) subunit + IL10
    
  • 3lqm - hIL10R β (mutant) subunit
    
  • 6x93 - hIL10R + IL10 – Cryo EM
    
  • 5t5w - hIL10R (mutant) + interferon lambda receptor 1 + interferon lambda-3
    
  • 9bpu, 9bpv - hIL10R + interferon lambda receptor 1 + interferon lambda-3 – Cryo EM
    
• Interleukin-20 receptor
  • 4doh - hIL20R α,β subunit + IL20
    
• Interleukin-22 receptor
  • 3g9v - hIL22R α subunit + IL22
    
  • 3dgc – hIL22R α (mutant) subunit + IL22
    
  • 3dlq - hIL22R α (mutant) subunit + IL2 (mutant)
    
  • 6df3 - hIL22R α subunit + hIL20R β subunit + IL24
    
• Interleukin-28 receptor
  • 3og4, 3og6 - hIL28R α subunit + IL29
    
• Interleukin receptor of immunoglobulin family
• Interleukin-1 receptor (CD121a, CD121b)
  • 1itb – hI1R1 extracellular domain + IL1 β
    
  • 1ira- hI1R1 extracellular domain + I1R1A
    
  • 1g0y - hI1R1 extracellular domain + I1R1A peptide
    
  • 3o4o - hI1R2 + IL1 β
    
  • 4dep – hIL1R1 extracellular domain + IL1 β + + IL1 accessory protein
    
  • 4gaf – hIL1R1 extracellular domain + IL1β/IL1RA
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel