Crystallin: Difference between revisions
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<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D- | <StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystallin, [[2g98]]'> | ||
== Function == | == Function == | ||
''' | '''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. '''α-, β-, γ-, δ-crystallin''' are named according to the order they are eluted by gel filtration. | ||
*'''Alpha crystallin''' has chaperone-like properties like the ability to prevent precipitation of denatured proteins<ref>PMID:15575808</ref>. See [[Alpha crystallin]]. | |||
*'''Gamma crystallin''' is found mainly in the nuclear region of the lens<ref>PMID:26116913</ref>. | |||
*.''' δ-crystallin''' is found in avian and reptilian lenses and missing from fish, amphibia and mammals lenses<ref>PMID:6369110</ref>. | |||
== Disease == | == Disease == | ||
Several human cataracts have been linked to mutations in γ-D- | Mutations in α-A-crystallin and α-B-crystallin can cause myopathy<ref>PMID:12565801</ref>. Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>. | ||
== 3D Structures of Crystallin == | |||
[[Crystallin 3D structures]] | |||
</StructureSection> | |||
== References == | == References == | ||
Latest revision as of 08:46, 9 June 2024
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