5nip: Difference between revisions
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New page: '''Unreleased structure''' The entry 5nip is ON HOLD Authors: Mir, B., Soles, X., Gonzalez, C., Escaja, N. Description: An i-motif containing the neutral cytidine protonated analogue p... |
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==An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine== | |||
<StructureSection load='5nip' size='340' side='right'caption='[[5nip]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5nip]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NIP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8YN:Pseudoisocytidine'>8YN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nip OCA], [https://pdbe.org/5nip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nip RCSB], [https://www.ebi.ac.uk/pdbsum/5nip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nip ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Incorporation of pseudoisocytidine (psC), a neutral analogue of protonated cytidine, in i-motifs has been studied by spectroscopic methods. Our results show that neutral psC:C base pairs can stabilize i-motifs at neutral pH, but the stabilization only occurs when psC:C base pairs are located at the ends of intercalated C:C+ stacks. When psC occupies central positions, the resulting i-motifs are only observed at low pH and psC:C+ or psC:psC+ hemiprotonated base pairs are formed instead of their neutral analogs. Overall, our results suggest that positively charged base pairs are necessary to stabilize this non-canonical DNA structure. | |||
The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures.,Mir B, Soles X, Gonzalez C, Escaja N Sci Rep. 2017 Jun 5;7(1):2772. doi: 10.1038/s41598-017-02723-y. PMID:28584239<ref>PMID:28584239</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5nip" style="background-color:#fffaf0;"></div> | ||
[[Category: Gonzalez | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Escaja N]] | |||
[[Category: Gonzalez C]] | |||
[[Category: Mir B]] | |||
[[Category: Soles X]] | |||
Latest revision as of 13:00, 15 November 2023
An i-motif containing the neutral cytidine protonated analogue pseudoisocytidine
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