Disintegrin: Difference between revisions
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<StructureSection load=' | <StructureSection load='' size='350' side='right' scene='Disintegrin/Cv/1' caption='Disintegrin, [[1z1x]]'> | ||
== Function == | |||
[[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | [[Disintegrin|Disintegrins]] are a family of cysteine-rich toxins from viper venoms which inhibit platelet aggregation and cell adhesion. <ref>PMID:15578957</ref> Over 100 disintegrins have been studied. | ||
== Relevance == | |||
Disintegrins which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | Disintegrins, which have anti-integrin activity, have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer. Disintegrin also functions in inhibition of adipogenesis<ref>PMID:18508683</ref>. | ||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Disintegrin == | == 3D Structures of Disintegrin == | ||
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[[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br /> | [[1j2l]] – trimestatin - ''Trimeresurus flavovidrius''<br /> | ||
[[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br /> | [[2pjf]], [[1q7i]], [[1q7j]], [[1n4y]] – Cr rhodostoxin residues 1-68 – ''Calloselasma rhodostoma'' – NMR<br /> | ||
[[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) – NMR<br /> | [[2pjg]], [[2pji]], [[2ljv]] - Cr rhodostoxin (mutant) 1-68 – NMR<br /> | ||
[[3uci]] - Cr rhodostoxin (mutant)<br /> | [[3uci]], [[26qz]], [[4r5r]], [[4r5u]], [[4rqg]] - Cr rhodostoxin (mutant) 408-475<br /> | ||
[[ | [[2m75]], [[2m7f]], [[2m7h]] - Cr rhodostoxin (mutant) 408-475 – NMR<br /> | ||
[[ | |||
[[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br /> | [[1z1x]], [[1tej]] – Ec disintegrin – ''Echis carinatus''<br /> | ||
[[1rmr]] – Ec schistatin<br /> | [[1rmr]] – Ec schistatin<br /> | ||
[[6lsq]] – Ec echistatin<br /> | |||
[[1ro3]], [[2ech]] – Ec echistatin - NMR<br /> | [[1ro3]], [[2ech]] – Ec echistatin - NMR<br /> | ||
[[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br /> | [[1l3x]] – salmosin – ''Gloydius brevicaudus'' – NMR<br /> | ||
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[[2dw0]], [[2dw1]], [[2dw2]] – catrocollastatin – rattlesnake<br /> | [[2dw0]], [[2dw1]], [[2dw2]] – catrocollastatin – rattlesnake<br /> | ||
[[2mop]], [[2mp5]] – bitistatin – African puff adder - NMR<br /> | [[2mop]], [[2mp5]] – bitistatin – African puff adder - NMR<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:41, 3 June 2026
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3D Structures of Disintegrin
Updated on 03-June-2026
2w9o, 2w9u, 2w9v, 2w9w – jerdostatin residues 68-110 – Trimeresurus jerdonii – NMR
1j2l – trimestatin - Trimeresurus flavovidrius
2pjf, 1q7i, 1q7j, 1n4y – Cr rhodostoxin residues 1-68 – Calloselasma rhodostoma – NMR
2pjg, 2pji, 2ljv - Cr rhodostoxin (mutant) 1-68 – NMR
3uci, 26qz, 4r5r, 4r5u, 4rqg - Cr rhodostoxin (mutant) 408-475
2m75, 2m7f, 2m7h - Cr rhodostoxin (mutant) 408-475 – NMR
1z1x, 1tej – Ec disintegrin – Echis carinatus
1rmr – Ec schistatin
6lsq – Ec echistatin
1ro3, 2ech – Ec echistatin - NMR
1l3x – salmosin – Gloydius brevicaudus – NMR
1mpz – obtustatin – Macrovipera obtusa - NMR
3c05 – acostatin-α residues 48-109+acostatin-β residues 419-482 – copperhead
3dsl – bothropasin - Jararaca
2dw0, 2dw1, 2dw2 – catrocollastatin – rattlesnake
2mop, 2mp5 – bitistatin – African puff adder - NMR
References
Proteopedia Page Contributors and Editors (what is this?)
Alexander Berchansky, Michal Harel, Eric Martz, Joel L. Sussman
