Severin: Difference between revisions

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<StructureSection load='1svy' size='350' side='right' scene='41/410299/Cv/6' caption='Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions [[1svy]]'>
<StructureSection load='1svy' size='350' side='right' scene='41/410299/Cv/6' caption='Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions [[1svy]]' pspeed='8'>




[[Severin]] is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin  and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins<ref>PMID:15060630</ref>. It is named Adseverin and Scinderin as well.
[[Severin]] is a calcium-activated protein which binds actin. It nucleates actin assembly, severes F-actin  and caps actin filaments. Severin is a member of the calcium-regulated gelsolin superfamily of actin severing and capping proteins<ref>PMID:15060630</ref>. It is named Adseverin and Scinderin as well.  
 
*<scene name='41/410299/Cv/9'>Ca coordination site</scene>. Water molecules are shown as red spheres.
*<scene name='41/410299/Cv/10'>Na coordination site</scene>.


</StructureSection>
</StructureSection>


== 3D Structures of Severin ==
== 3D Structures of Severin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3fg6]] – Adseverin C-terminal – human<br />
[[3fg6]] – Adseverin C-terminal – human<br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />
[[1svy]] – DdSeverin domain 2 – ''Dictyostelium discoideum'' <br />

Latest revision as of 10:26, 19 November 2023

Severin domain 2 complex with Ca+2 (green) and Na+ (purple) ions 1svy

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3D Structures of Severin

Updated on 19-November-2023

3fg6 – Adseverin C-terminal – human
1svy – DdSeverin domain 2 – Dictyostelium discoideum
1svq, 1svr - DdSeverin domain 2 - NMR

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Jaime Prilusky, Michal Harel