6b11: Difference between revisions

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'''Unreleased structure'''


The entry 6b11 is ON HOLD
==TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)==
 
<StructureSection load='6b11' size='340' side='right'caption='[[6b11]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
Authors: DeMars, M.D., Sherman, D.H., Podust, L.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6b11]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_fradiae Streptomyces fradiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B11 FirstGlance]. <br>
Description: TylHI in complex with native substrate 23-deoxy-5-O-mycaminosyl-tylonolide (23-DMTL)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CGM:(4R,5S,6S,7R,9R,11E,13E,15S,16R)-16-ethyl-4-hydroxy-5,9,13,15-tetramethyl-2,10-dioxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-6-yl+3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranoside'>CGM</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
[[Category: Demars, M.D]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b11 OCA], [https://pdbe.org/6b11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b11 RCSB], [https://www.ebi.ac.uk/pdbsum/6b11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b11 ProSAT]</span></td></tr>
[[Category: Sherman, D.H]]
</table>
[[Category: Podust, L.M]]
== Function ==
[https://www.uniprot.org/uniprot/TYLH1_STRFR TYLH1_STRFR] Involved in the biosynthesis of the complex macrolide antibiotic tylosin. Catalyzes the hydroxylation of 20-oxo-5-O-beta-mycaminosyltylactone at the C-23 position to yield 5-O-beta-mycaminosyltylonolide.<ref>PMID:7283418</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Streptomyces fradiae]]
[[Category: DeMars MD]]
[[Category: Podust LM]]
[[Category: Sherman DH]]
Retrieved from "https://proteopedia.org/6b11"