ERGIC-53

spinqualitylabelsall models Human ERGIC-53 carbohydrate recognition domain complex with mannose (stick model), glycerol and Ca+2 ion (green) (PDB code 4gky) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function ER-Golgi Intermediate Compartment-53 (ERGIC-53) is a transmembrane protein which acts as a receptor of glycoproteins and transports them from the ER to ER-Golgi Intermediate Compartment and Golgi. Relevance Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus. Structural highlights ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well. Water molecules are shown as red spheres.

3D structures of ERGIC-53

Updated on 03-June-2025

ERGIC-53; Domains – CRD 31-269

8jp4, 8jp5, 8jp6, 8jp7, 8jp8, 8jp9, 8jpg – hERGIC-53 + MCFD2 + Ca - human - Cryo EM
4ygb, 4ygc, 4ygd, 4yge, 3wht, 3lcp, 3a4u – hERGIC-53 CRD domain + MCFD2 + Ca
3whu, 3wnx – hERGIC-53 CRD domain + MCFD2 + Ca + mannose
4gkx – hERGIC-53 CRD domain + Ca
4gky – hERGIC-53 CRD domain + Ca + mannose
1r1z – rERGIC-53 CRD domain + Ca - rat
1gv9 – rERGIC-53 CRD domain

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