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==Crystal Structure of PRL-1 complex with compound analogy 3==
==Crystal Structure of PRL-1 complex with compound analogy 3==
<StructureSection load='5bx1' size='340' side='right' caption='[[5bx1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5bx1' size='340' side='right'caption='[[5bx1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5bx1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BX1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5bx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BX1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4XA:3-(5,6-DIMETHYL-2H-ISOINDOL-2-YL)-N-[(E)-FURAN-2-YLMETHYLIDENE]BENZOHYDRAZIDE'>4XA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zck|1zck]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4XA:3-(5,6-DIMETHYL-2H-ISOINDOL-2-YL)-N-[(E)-FURAN-2-YLMETHYLIDENE]BENZOHYDRAZIDE'>4XA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP4A1, PRL1, PTPCAAX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bx1 OCA], [https://pdbe.org/5bx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bx1 RCSB], [https://www.ebi.ac.uk/pdbsum/5bx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bx1 ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bx1 OCA], [http://pdbe.org/5bx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5bx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5bx1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TP4A1_HUMAN TP4A1_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.<ref>PMID:12235145</ref> <ref>PMID:14643450</ref> <ref>PMID:12782572</ref>
[https://www.uniprot.org/uniprot/TP4A1_HUMAN TP4A1_HUMAN] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.<ref>PMID:12235145</ref> <ref>PMID:14643450</ref> <ref>PMID:12782572</ref>  
 
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Bai, Y]]
[[Category: Bai Y]]
[[Category: Liu, S]]
[[Category: Liu S]]
[[Category: Zhang, Z]]
[[Category: Zhang Z]]
[[Category: Detrimerizer]]
[[Category: Hydrolase]]
[[Category: Interface]]
[[Category: Monomer]]
[[Category: Protein tyrosine phosphatase]]

Latest revision as of 08:32, 27 September 2023

Crystal Structure of PRL-1 complex with compound analogy 3

5bx1, resolution 1.90Å

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