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==Structure of the Ca2+-bound Rabphilin 3A C2B domain SNAP25 complex (P21 space group)==
==Structure of the Ca2+-bound Rabphilin 3A C2B domain SNAP25 complex (P21 space group)==
<StructureSection load='5low' size='340' side='right' caption='[[5low]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5low' size='340' side='right'caption='[[5low]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5low]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LOW FirstGlance]. <br>
<table><tr><td colspan='2'>[[5low]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LOW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rph3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Snap25, Snap ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5low FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5low OCA], [http://pdbe.org/5low PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5low RCSB], [http://www.ebi.ac.uk/pdbsum/5low PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5low ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5low FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5low OCA], [https://pdbe.org/5low PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5low RCSB], [https://www.ebi.ac.uk/pdbsum/5low PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5low ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RP3A_RAT RP3A_RAT]] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal. [[http://www.uniprot.org/uniprot/SNP25_RAT SNP25_RAT]] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.  
[https://www.uniprot.org/uniprot/RP3A_RAT RP3A_RAT] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5low" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5low" style="background-color:#fffaf0;"></div>
==See Also==
*[[Exophilin 3D structures|Exophilin 3D structures]]
*[[Rabphilin|Rabphilin]]
*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Ferrer-Orta, C]]
[[Category: Rattus norvegicus]]
[[Category: Verdaguer, N]]
[[Category: Ferrer-Orta C]]
[[Category: C2 domain]]
[[Category: Verdaguer N]]
[[Category: Calcium]]
[[Category: Exocytosis]]
[[Category: Membrane fusion]]

Latest revision as of 18:38, 18 October 2023

Structure of the Ca2+-bound Rabphilin 3A C2B domain SNAP25 complex (P21 space group)

5low, resolution 2.80Å

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