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[[Image:2cnq.gif|left|200px]]


{{Structure
==Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate==
|PDB= 2cnq |SIZE=350|CAPTION= <scene name='initialview01'>2cnq</scene>, resolution 1.00&Aring;
<StructureSection load='2cnq' size='340' side='right'caption='[[2cnq]], [[Resolution|resolution]] 1.00&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+A'>AC2</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
<table><tr><td colspan='2'>[[2cnq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CNQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CNQ FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylaminoimidazolesuccinocarboxamide_synthase Phosphoribosylaminoimidazolesuccinocarboxamide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.6 6.3.2.6] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=AMZ:AMINOIMIDAZOLE+4-CARBOXAMIDE+RIBONUCLEOTIDE'>AMZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cnq OCA], [https://pdbe.org/2cnq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cnq RCSB], [https://www.ebi.ac.uk/pdbsum/2cnq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cnq ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cnq OCA], [http://www.ebi.ac.uk/pdbsum/2cnq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cnq RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PUR7_YEAST PUR7_YEAST]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cn/2cnq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cnq ConSurf].
<div style="clear:both"></div>


'''ATOMIC RESOLUTION STRUCTURE OF SAICAR-SYNTHASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH ADP, AICAR, SUCCINATE'''
==See Also==
 
*[[SAICAR synthetase|SAICAR synthetase]]
 
__TOC__
==About this Structure==
</StructureSection>
2CNQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CNQ OCA].
[[Category: Large Structures]]
[[Category: Phosphoribosylaminoimidazolesuccinocarboxamide synthase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Antonyuk SV]]
[[Category: Antonyuk, S V.]]
[[Category: Barynin VV]]
[[Category: Barynin, V V.]]
[[Category: Grebenko AI]]
[[Category: Grebenko, A I.]]
[[Category: Lamzin VS]]
[[Category: Lamzin, V S.]]
[[Category: Levdikov VM]]
[[Category: Levdikov, V M.]]
[[Category: Melik-Adamyan WR]]
[[Category: Melik-Adamyan, W R.]]
[[Category: Popov AN]]
[[Category: Popov, A N.]]
[[Category: Urusova DV]]
[[Category: Urusova, D V.]]
[[Category: acetylation]]
[[Category: atp-binding protein]]
[[Category: phosphoribosylaminoimidazolesuccinocarboxamide (saicar) syn ligase]]
[[Category: purine biosynthesis]]
[[Category: synthetase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:24:06 2008''

Latest revision as of 14:24, 13 December 2023

Atomic resolution structure of SAICAR-synthase from Saccharomyces cerevisiae complexed with ADP, AICAR, succinate

2cnq, resolution 1.00Å

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