6c0v: Difference between revisions

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==Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation==
==Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation==
<StructureSection load='6c0v' size='340' side='right' caption='[[6c0v]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
<SX load='6c0v' size='340' side='right' viewer='molstar' caption='[[6c0v]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c0v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C0V FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c0v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C0V FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0v OCA], [http://pdbe.org/6c0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c0v RCSB], [http://www.ebi.ac.uk/pdbsum/6c0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0v ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0v OCA], [https://pdbe.org/6c0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c0v RCSB], [https://www.ebi.ac.uk/pdbsum/6c0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0v ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN]] Ulcerative colitis. Disease susceptibility is associated with variations affecting the gene represented in this entry.  
[https://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN] Ulcerative colitis. Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.  
[https://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
__TOC__
__TOC__
</StructureSection>
</SX>
[[Category: Xenobiotic-transporting ATPase]]
[[Category: Homo sapiens]]
[[Category: Chen, J]]
[[Category: Large Structures]]
[[Category: Kim, Y J]]
[[Category: Chen J]]
[[Category: Abc transporter]]
[[Category: Kim YJ]]
[[Category: Abcb1]]
[[Category: Cryo-em]]
[[Category: Multidrug resistance]]
[[Category: P-glycoprotein]]
[[Category: PSI, Protein structure initiative]]
[[Category: Structural genomic]]
[[Category: Transport protein]]
Retrieved from "https://proteopedia.org/6c0v"