6cd6: Difference between revisions
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==Crystal Structure of the Human CAMKK1A in complex with GSK650394== | |||
<StructureSection load='6cd6' size='340' side='right'caption='[[6cd6]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6cd6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CD6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DXV:2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic+acid'>DXV</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cd6 OCA], [https://pdbe.org/6cd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cd6 RCSB], [https://www.ebi.ac.uk/pdbsum/6cd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cd6 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KKCC1_HUMAN KKCC1_HUMAN] Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.<ref>PMID:12935886</ref> | |||
==See Also== | |||
*[[Calcium/calmodulin-dependent protein kinase kinase|Calcium/calmodulin-dependent protein kinase kinase]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arruda P]] | ||
[[Category: | [[Category: Counago RM]] | ||
[[Category: | [[Category: Drewry D]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Elkins JM]] | ||
[[Category: Santiago | [[Category: Massirer KB]] | ||
[[Category: | [[Category: Ramos PZ]] | ||
[[Category: Righetto GL]] | |||
[[Category: Santiago AS]] | |||
[[Category: Silva PNB]] | |||
Latest revision as of 15:01, 4 October 2023
Crystal Structure of the Human CAMKK1A in complex with GSK650394
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