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==Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus==
==Discovery and structural analysis of a phloretin hydrolase from the opportunistic pathogen Mycobacterium abscessus==
<StructureSection load='5xey' size='340' side='right' caption='[[5xey]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
<StructureSection load='5xey' size='340' side='right'caption='[[5xey]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5xey]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XEY FirstGlance]. <br>
<table><tr><td colspan='2'>[[5xey]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XEY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=83X:1-[2,4,6-tris(oxidanyl)phenyl]ethanone'>83X</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5xe5|5xe5]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=83X:1-[2,4,6-tris(oxidanyl)phenyl]ethanone'>83X</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xey OCA], [http://pdbe.org/5xey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xey RCSB], [http://www.ebi.ac.uk/pdbsum/5xey PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xey ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xey OCA], [https://pdbe.org/5xey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xey RCSB], [https://www.ebi.ac.uk/pdbsum/5xey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xey ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHY_MYCA9 PHY_MYCA9] Catalyzes the hydrolytic C-C cleavage of phloretin to phloroglucinol and 3-(4-hydroxyphenyl)propionic acid. Can also hydrolyze monoacetylphloroglucinol (MAPG) but not 2,4-diacetylphloroglucinol (DAPG).<ref>PMID:30784195</ref>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Han, J T]]
[[Category: Large Structures]]
[[Category: He, Y X]]
[[Category: Mycobacteroides abscessus ATCC 19977]]
[[Category: Jia, W J]]
[[Category: Han JT]]
[[Category: Zhang, Z]]
[[Category: He YX]]
[[Category: Bet v1 fold]]
[[Category: Jia WJ]]
[[Category: C-c bond]]
[[Category: Zhang Z]]
[[Category: Flavonoid]]
[[Category: Hydrolase]]
[[Category: Phloretin hydrolase]]
Retrieved from "https://proteopedia.org/5xey"