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==Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain==
==Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain==
<StructureSection load='6c7y' size='340' side='right' caption='[[6c7y]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='6c7y' size='340' side='right'caption='[[6c7y]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6c7y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C7Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C7Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[6c7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6C7Y FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.499&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6c5x|6c5x]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6c7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c7y OCA], [https://pdbe.org/6c7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6c7y RCSB], [https://www.ebi.ac.uk/pdbsum/6c7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6c7y ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c7y OCA], [http://pdbe.org/6c7y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c7y RCSB], [http://www.ebi.ac.uk/pdbsum/6c7y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c7y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.  
[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6c7y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6c7y" style="background-color:#fffaf0;"></div>
==See Also==
*[[Janus kinase 3D structures|Janus kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Gallus gallus]]
[[Category: Babon, J J]]
[[Category: Homo sapiens]]
[[Category: Callaghan, K]]
[[Category: Large Structures]]
[[Category: Kershaw, N J]]
[[Category: Babon JJ]]
[[Category: Laktyushin, A]]
[[Category: Callaghan K]]
[[Category: Liau, N P.D]]
[[Category: Kershaw NJ]]
[[Category: Lucet, I S]]
[[Category: Laktyushin A]]
[[Category: Murphy, J M]]
[[Category: Liau NPD]]
[[Category: Nicola, N A]]
[[Category: Lucet IS]]
[[Category: Yao, S]]
[[Category: Murphy JM]]
[[Category: Kinase]]
[[Category: Nicola NA]]
[[Category: Kinase inhibitor]]
[[Category: Yao S]]
[[Category: Signaling protein]]
[[Category: Transferase-inhibitor complex]]

Latest revision as of 14:57, 4 October 2023

Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain

6c7y, resolution 2.50Å

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