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[[Image:2ji5.gif|left|200px]]


{{Structure
==Structure of UMP kinase from Pyrococcus furiosus complexed with UTP==
|PDB= 2ji5 |SIZE=350|CAPTION= <scene name='initialview01'>2ji5</scene>, resolution 2.45&Aring;
<StructureSection load='2ji5' size='340' side='right'caption='[[2ji5]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Utp+Binding+Site+For+Chain+A'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=UTP:URIDINE+5&#39;-TRIPHOSPHATE'>UTP</scene>
<table><tr><td colspan='2'>[[2ji5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JI5 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ji5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ji5 OCA], [https://pdbe.org/2ji5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ji5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ji5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ji5 ProSAT]</span></td></tr>
|RELATEDENTRY=[[2bmu|2BMU]], [[2bri|2BRI]], [[2brx|2BRX]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ji5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ji5 OCA], [http://www.ebi.ac.uk/pdbsum/2ji5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ji5 RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/PYRH_PYRFU PYRH_PYRFU] Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor.<ref>PMID:15698963</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ji/2ji5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ji5 ConSurf].
<div style="clear:both"></div>


'''STRUCTURE OF UMP KINASE FROM PYROCOCCUS FURIOSUS COMPLEXED WITH UTP'''
==See Also==
 
*[[Uridylate kinase|Uridylate kinase]]
 
== References ==
==About this Structure==
<references/>
2JI5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JI5 OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
[[Category: Single protein]]
[[Category: Marco-Marin C]]
[[Category: Marco-Marin, C.]]
[[Category: Rubio V]]
[[Category: Rubio, V.]]
[[Category: allosteric regulation]]
[[Category: amino acid kinase]]
[[Category: kinase]]
[[Category: phosphotranspherase]]
[[Category: pyrimidine biosynthesis]]
[[Category: pyrimidine metabolism]]
[[Category: transferase]]
[[Category: ump kinase]]
[[Category: uridylate kinase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:58:31 2008''

Latest revision as of 14:49, 13 December 2023

Structure of UMP kinase from Pyrococcus furiosus complexed with UTP

2ji5, resolution 2.45Å

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