6dte: Difference between revisions
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==GlcNAc-inspired cyclophellitol bound to NagZ== | |||
<StructureSection load='6dte' size='340' side='right'caption='[[6dte]], [[Resolution|resolution]] 1.93Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6dte]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6DTE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.929Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=H9J:2,2,2-tris(fluoranyl)-~{N}-[(2~{R},3~{R},5~{R},6~{R})-4-(hydroxymethyl)-2,3,5,6-tetrakis(oxidanyl)cyclohexyl]ethanamide'>H9J</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6dte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dte OCA], [https://pdbe.org/6dte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6dte RCSB], [https://www.ebi.ac.uk/pdbsum/6dte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6dte ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A125HFC0_9BURK A0A125HFC0_9BURK] Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.[HAMAP-Rule:MF_00364][SAAS:SAAS00634279] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The development of a potent mechanism-based inactivator of NagZ, an enzyme critical to the production of inducible AmpC beta-lactamase in Gram-negative bacteria, is presented. This inactivator significantly reduces MIC values for important beta-lactams against a clinically relevant strain of Pseudomonas aeruginosa. | |||
A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to beta-lactams in Pseudomonas aeruginosa.,Ho LA, Winogrodzki JL, Debowski AW, Madden Z, Vocadlo DJ, Mark BL, Stubbs KA Chem Commun (Camb). 2018 Sep 25;54(75):10630-10633. doi: 10.1039/c8cc05281f. Epub, 2018 Sep 4. PMID:30178799<ref>PMID:30178799</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6dte" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
==See Also== | |||
*[[Beta-Hexosaminidase|Beta-Hexosaminidase]] | |||
*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]] | |||
*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Burkholderia cenocepacia]] | |||
[[Category: Large Structures]] | |||
[[Category: Mark BL]] | |||
[[Category: Winogrodzki JL]] | |||
Latest revision as of 07:53, 17 October 2024
GlcNAc-inspired cyclophellitol bound to NagZ
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