6ebr: Difference between revisions
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New page: '''Unreleased structure''' The entry 6ebr is ON HOLD Authors: Riboldi-Tunnicliffe, A., Panjikar, S. Description: Activation of RR02 bound to BeF3 Category: Unreleased Structures [[... |
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==Activation of RR02 bound to BeF3== | |||
<StructureSection load='6ebr' size='340' side='right'caption='[[6ebr]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ebr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EBR FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.816Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ebr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ebr OCA], [https://pdbe.org/6ebr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ebr RCSB], [https://www.ebi.ac.uk/pdbsum/6ebr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ebr ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/WALR_STRPN WALR_STRPN] Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism (By similarity). Binds to the promoter region of the transcription factor fabT gene in the fabTH-acp operon in vitro (PubMed:27610104). Inhibits transcription of fabT, probably acting in an unphosphorylated form, thereby playing a role in the regulation of fatty acid biosynthesis (PubMed:15774879, PubMed:27610104). Essential for normal growth in vitro (By similarity). Required for maintaining normal cellular morphology, acting, at least in part, by regulating peptidoglycan hydrolase pcsB (By similarity). Involved in maintaining expression of WalRK regulon genes in exponentially growing cells (By similarity).[UniProtKB:A0A0H2ZN37][UniProtKB:P37478][UniProtKB:Q8DPL7]<ref>PMID:15774879</ref> <ref>PMID:27610104</ref> | |||
==See Also== | |||
*[[Response regulator 3D structure|Response regulator 3D structure]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Panjikar | __TOC__ | ||
[[Category: Riboldi-Tunnicliffe | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Streptococcus pneumoniae TIGR4]] | |||
[[Category: Panjikar S]] | |||
[[Category: Riboldi-Tunnicliffe A]] | |||
