Outer surface protein

spinqualitylabelsall models Outer surface protein A (PDB entry 2af5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Outer surface proteins (Osp) are produced by the bacteria Borrelia burgdorferi which causes Lyme disease. OspA and OspB are upregulated when the bacteria enter the tick. OspA contributes to the colonization of the gut by the bacteria. OspB, OspC and OspE are major antigens on the surface of the Lyme disease spirochetes when it is being transmitted to humans. For more details see: OspA - G09SecL04Tpc2 G1SecL05 OspA OspA L03 Group2 OspB - Outer surface protein B (OspB) of the Lyme disease spirochete bacterium G14secL04Tpc3 G04SecL04Tpc1 G15SecL05Tpc3 G13secL03Tpc3 G12SecL02Tpc3 OspC - OspC and Binding SB2013 L08gr01 G18secL03Tpc4. OxpA, OspB and OspC - Highlighted Proteins of Lyme Disease

3D structures of Outer surface proteins (Updated on 13-April-2026)

{"openlevels":0}

• OspA
  • G09SecL04Tpc2, G1SecL05, OspA, OspA L03 Group2, Outer surface protein B (OspB) of the Lyme disease spirochete bacterium, G14secL04Tpc3, G04SecL04Tpc1, G15SecL05Tpc3, G13secL03Tpc3, G12SecL02Tpc3, OspC and Binding – BbOspA – Borrelia burgdorferi
    
  • SB2013 L08gr01, G18secL03Tpc4, Highlighted Proteins of Lyme Disease, 2ol7, 2ol8, 2oy1, 2i5v, 2oy5, 2oy7, 2oy8, 2pi3, 3aum, 3cka,
  • 3ckf, 3ckg, 3ec5, 3eex, 6j49, 6j48, 5b2a, 6j47, 5ys7, 5z1o, 6ais, 6ics, 6idc, 6iei, 6iys, 6j47, 6j48, 6j49, 6j5m, 6j5n, 6j5o, 6j5p, 6j5q, 6j5r, 6kt1, 6ljy, 6kk9, 6kwj, 6kwu, 6kwv, 7fdd, 7fjr - OspA (mutant)
    
  • 5izt – OspA C-terminal
    
  • 7jwg, 7t25, 8tuz, 8tv3, 8tvd, 9byf, 9cds – OspA + antibody
    
  • 1osp, 1fj1 – OspA (mutant) + antibody
    
• OspB
  • 2yn7 – OspB
    
  • 1p4p – OspB C terminal
    
  • 1rjl - OspB+ antibody
    
• OspC
  • 1ggq, 1g5z, 7bml – OspC
    
  • 1f1m – OspC (mutant)
    
  • 9bif, 9c1s – OspC type A + antibody
    
  • 7uj2 – OspC type B
    
  • 9c24 – OspC type B + antibody
    
  • 7uj2 – OspC type B
    
  • 7uj6 – OspC type K
    
  • 7uij – OspC + antibody
    
  • 7nen – OspC – Borrelia garinii
    
• OspE
  • 2m4f – OspE – NMR
    
  • 4j38 – OspE + complement factor H
    
  • 5nbq – OspE + complement factor H + complement C3
    
• Paralogous family 12 Osp
  • 8s2f, 8s2p – BBH37
    
  • 8cqn, 8cqo – BBK01
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky