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==A mechanism for the activation of the influenza virus transcriptase==
==A mechanism for the activation of the influenza virus transcriptase==
<StructureSection load='6f5p' size='340' side='right' caption='[[6f5p]], [[Resolution|resolution]] 4.14&Aring;' scene=''>
<StructureSection load='6f5p' size='340' side='right'caption='[[6f5p]], [[Resolution|resolution]] 4.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6f5p]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F5P FirstGlance]. <br>
<table><tr><td colspan='2'>[[6f5p]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Fopius_arisanus Fopius arisanus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_C_virus_(C/Johannesburg/1/66) Influenza C virus (C/Johannesburg/1/66)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F5P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.14&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f5p OCA], [https://pdbe.org/6f5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f5p RCSB], [https://www.ebi.ac.uk/pdbsum/6f5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f5p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f5p OCA], [http://pdbe.org/6f5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f5p RCSB], [http://www.ebi.ac.uk/pdbsum/6f5p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f5p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PA_INCJH PA_INCJH]] Implicated in endonuclease cleavage of capped RNA primers. Displays an elongation factor activity in viral RNA synthesis. Dispensable for viral transcription, but not replication (By similarity). [[http://www.uniprot.org/uniprot/PB2_INCJH PB2_INCJH]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1 (By similarity). [[http://www.uniprot.org/uniprot/RDRP_INCJH RDRP_INCJH]] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6f5p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6f5p" style="background-color:#fffaf0;"></div>
==See Also==
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: RNA-directed RNA polymerase]]
[[Category: Fopius arisanus]]
[[Category: Grimes, J M]]
[[Category: Homo sapiens]]
[[Category: Martin, I Serna]]
[[Category: Large Structures]]
[[Category: Influenza virus rna polymerase]]
[[Category: Grimes JM]]
[[Category: Pol ii]]
[[Category: Serna Martin I]]
[[Category: Replication]]
[[Category: Transcription]]

Latest revision as of 07:56, 17 October 2024

A mechanism for the activation of the influenza virus transcriptase

6f5p, resolution 4.14Å

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