Colony-stimulating factor: Difference between revisions

Latest revision as of 14:01, 11 May 2021

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Glycosylated human macrophage colony-stimulating factor (deeppink and salmon) complex with macrophage colony-stimulating factor 1 receptor (deepskyblue and green) (PDB code 4wrl)

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Function

Colony-stimulating factors (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells. Four distinct CSFs were characterized^[1].

Granulocyte colony-stimulating factor (G-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes^[2].
Macrophage colony-stimulating factor (M-CSF) or lanimostin acts on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.
multi-colony-stimulating factor also known as interleukin 3.

Relevance

Depletion of CSFs have therapeutic benefit in many inflammatory and autoimmune conditions^[3]. G-CSF and GM-CSF are used to increase low white blood cell levels in cancer patients following chemotherapy and to release haematopoietic stem cells which replace bone marrow cells after anti-cancer treatments^[4]. G-CSF is a neurotrophic factor and thus a candidate for the treatment of neurodegenerative conditions^[5]. G-CSF and GN-CSF ar commercially available for clinical use^[6].

Structural highlights

The structure of the complex between M-CSF and its receptor shows that a dimer of M-CSF binds to 2 molecules of the receptor. There are two binding sites between the molecules designated site I and site II^[7]. All interactions. See also Colony-stimulating factor receptor

3D structures of colony-stimulating factor

Colony-stimulating factor 3D structures

↑ Nemunaitis J. A comparative review of colony-stimulating factors. Drugs. 1997 Nov;54(5):709-29. doi: 10.2165/00003495-199754050-00004. PMID:9360058 doi:https://dx.doi.org/10.2165/00003495-199754050-00004
↑ Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017. PMID:16474424 doi:https://dx.doi.org/10.1038/sj.cr.7310017
↑ Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356. PMID:18551128 doi:https://dx.doi.org/10.1038/nri2356
↑ Metcalf D. The colony-stimulating factors and cancer. Nat Rev Cancer. 2010 Jun;10(6):425-34. doi: 10.1038/nrc2843. PMID:20495576 doi:https://dx.doi.org/10.1038/nrc2843
↑ Schneider A, Kuhn HG, Schabitz WR. A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle. 2005 Dec;4(12):1753-7. doi: 10.4161/cc.4.12.2213. Epub 2005 Dec 27. PMID:16258290 doi:https://dx.doi.org/10.4161/cc.4.12.2213
↑ Lieschke GJ, Burgess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N Engl J Med. 1992 Jul 2;327(1):28-35. doi: 10.1056/NEJM199207023270106. PMID:1375975 doi:https://dx.doi.org/10.1056/NEJM199207023270106
↑ Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:https://dx.doi.org/10.1016/j.str.2015.06.019

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Nemunaitis J. A comparative review of colony-stimulating factors. Drugs. 1997 Nov;54(5):709-29. doi: 10.2165/00003495-199754050-00004. PMID:9360058 doi:https://dx.doi.org/10.2165/00003495-199754050-00004

[2] Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33. doi: 10.1038/sj.cr.7310017. PMID:16474424 doi:https://dx.doi.org/10.1038/sj.cr.7310017

[3] Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol. 2008 Jul;8(7):533-44. doi: 10.1038/nri2356. PMID:18551128 doi:https://dx.doi.org/10.1038/nri2356

[4] Metcalf D. The colony-stimulating factors and cancer. Nat Rev Cancer. 2010 Jun;10(6):425-34. doi: 10.1038/nrc2843. PMID:20495576 doi:https://dx.doi.org/10.1038/nrc2843

[5] Schneider A, Kuhn HG, Schabitz WR. A role for G-CSF (granulocyte-colony stimulating factor) in the central nervous system. Cell Cycle. 2005 Dec;4(12):1753-7. doi: 10.4161/cc.4.12.2213. Epub 2005 Dec 27. PMID:16258290 doi:https://dx.doi.org/10.4161/cc.4.12.2213

[6] Lieschke GJ, Burgess AW. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N Engl J Med. 1992 Jul 2;327(1):28-35. doi: 10.1056/NEJM199207023270106. PMID:1375975 doi:https://dx.doi.org/10.1056/NEJM199207023270106

[7] Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN. Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1. Structure. 2015 Jul 21. pii: S0969-2126(15)00272-5. doi:, 10.1016/j.str.2015.06.019. PMID:26235028 doi:https://dx.doi.org/10.1016/j.str.2015.06.019

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+<StructureSection load='4wrl' size='340' side='right' caption='Glycosylated human macrophage colony-stimulating factor (deeppink and salmon) complex with macrophage colony-stimulating factor 1 receptor (deepskyblue and green) (PDB code [[4wrl]])' scene='80/801266/Cv/1'>
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-This is a default text for your page '''Colony-stimulating factor'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 == Function ==
-'''Colony-stimulating factor'''s (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells.  Three distinct CSFs were characterized<ref>PMID:9360058</ref>.<br />
+'''Colony-stimulating factor'''s (CSF) are growth regulatory factors which influence functional activity, survival, proliferation and differentiation of myeloid mature and haemopoietic cells.  Four distinct CSFs were characterized<ref>PMID:9360058</ref>.<br />
-*'''Granulocyte colony-stimulating factor''' (G-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils.<br />
+*'''Granulocyte colony-stimulating factor''' (G-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils.<br />
-*'''Granulocyte-macrophage colony-stimulating factor''' (GM-CSF) act on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes.<br />
+*'''Granulocyte-macrophage colony-stimulating factor''' (GM-CSF) acts on proliferation, functional stimulation and differentiation of progenitors of neutrophils, monocytes and granulocytes<ref>PMID:16474424</ref>.<br />
-*'''Macrophage colony-stimulating factor''' (M-CSF) act on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.<br />
+*'''Macrophage colony-stimulating factor''' (M-CSF) or '''lanimostin''' acts on proliferation, functional stimulation and differentiation of progenitors of monocytes and macrophages.<br />
+*'''multi-colony-stimulating factor''' also known as interleukin 3.<br />
-== Disease ==
 == Relevance ==
-Depletin o CSFs have therapeutic benefit in many inflammatory and autoimmune conditions<ref>PMID:18551128</ref>.
+Depletion of CSFs have therapeutic benefit in many inflammatory and autoimmune conditions<ref>PMID:18551128</ref>.  G-CSF and GM-CSF are used to increase low white blood cell levels in cancer patients following chemotherapy and to release haematopoietic stem cells which replace bone marrow cells after anti-cancer treatments<ref>PMID:20495576</ref>.  G-CSF is a neurotrophic factor and thus a candidate for the treatment of neurodegenerative conditions<ref>PMID:16258290</ref>.  G-CSF and GN-CSF ar commercially available for clinical use<ref>PMID:1375975</ref>.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The structure of the complex between M-CSF and its receptor shows that a <scene name='80/801266/Cv/3'>dimer of M-CSF binds to 2 molecules of the receptor</scene>. There are <scene name='80/801266/Cv/5'>two binding sites between the molecules designated site I and site II</scene><ref>PMID:26235028</ref>. <scene name='80/801266/Cv/4'>All interactions</scene>. See also [[Colony-stimulating factor receptor]]
+==3D structures of colony-stimulating factor==
+[[Colony-stimulating factor 3D structures]]
 </StructureSection>
 == References ==
 <references/>
+[[Category:Topic Page]]

Colony-stimulating factor: Difference between revisions

Latest revision as of 14:01, 11 May 2021

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Function

Relevance

Structural highlights

3D structures of colony-stimulating factor

References

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