6cge: Difference between revisions
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==Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+== | ==Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+== | ||
<StructureSection load='6cge' size='340' side='right' caption='[[6cge]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='6cge' size='340' side='right'caption='[[6cge]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6cge]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGE OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6cge]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CGE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CGE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F0D:3- | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F0D:3-[[(8~{R},9~{S},13~{S},14~{S},16~{R},17~{S})-3-(2-bromoethyl)-13-methyl-17-oxidanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-16-yl]methyl]benzamide'>F0D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cge OCA], [https://pdbe.org/6cge PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cge RCSB], [https://www.ebi.ac.uk/pdbsum/6cge PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cge ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/DHB1_HUMAN DHB1_HUMAN] Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 6cge" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6cge" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Li T]] | ||
[[Category: | [[Category: Lin SX]] | ||
Latest revision as of 09:47, 23 October 2024
Crystal structure of human 17beta-HSD type 1 in ternary complex with PBRM and NADP+
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