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==Structure of the DNA binding domain of antitoxin CopASO==
==Structure of the DNA binding domain of antitoxin CopASO==
<StructureSection load='6iya' size='340' side='right' caption='[[6iya]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='6iya' size='340' side='right'caption='[[6iya]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6iya]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IYA FirstGlance]. <br>
<table><tr><td colspan='2'>[[6iya]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Shewanella_oneidensis_MR-1 Shewanella oneidensis MR-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IYA FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iya OCA], [http://pdbe.org/6iya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6iya RCSB], [http://www.ebi.ac.uk/pdbsum/6iya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6iya ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iya OCA], [https://pdbe.org/6iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iya RCSB], [https://www.ebi.ac.uk/pdbsum/6iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iya ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8EGZ2_SHEON Q8EGZ2_SHEON]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Toxin-antitoxin (TA) systems play critical roles in the environment adaptation of bacteria. Allosteric coupling between the N-terminal DNA-binding domain and the C-terminal toxin-binding domain of antitoxins contributes to conditional cooperativity in the functioning of type II TA. Herein, using circular dichroism (CD), nuclear magnetic resonance (NMR), X-ray crystallography, and size exclusion chromatography (SEC), the structure and DNA binding of CopASO, a newly identified type II antitoxin in Shewanella oneidensis, were investigated. Our data show that CopASO is a typical RHH antitoxin with an ordered N-terminal domain and a disordered C-terminal domain, and furthermore indicate that the C-terminal domain facilitates DNA binding of the N-terminal domain, which in turn induces the C-terminal domain to fold and associate.
Structure and allosteric coupling of type antitoxin CopASO.,Zhao R, Li Q, Zhang J, Li F, Yao J, Zhang J, Liu L, Wang X, Zhang X Biochem Biophys Res Commun. 2019 Jul 5;514(4):1122-1127. doi:, 10.1016/j.bbrc.2019.05.049. Epub 2019 May 14. PMID:31101334<ref>PMID:31101334</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 6iya" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Li, F]]
[[Category: Large Structures]]
[[Category: Liu, L]]
[[Category: Shewanella oneidensis MR-1]]
[[Category: Zhang, X]]
[[Category: Li F]]
[[Category: Zhao, R]]
[[Category: Liu L]]
[[Category: Antitoxin]]
[[Category: Zhang X]]
[[Category: Dna binding]]
[[Category: Zhao R]]
[[Category: Rhh]]
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